This is an application for competitive renewal of a Program Project Grant that has been active for 39 years. It involves many investigators and many different projects, all relating to the improvement of the results of solid organ transplantation. The basic overall OBJECTIVES of this grant are to: A. isolate and analyze clinical problems in solid organ transplantation and precisely document clinical/laboratory correlations; B. organize clinical trials and experimental approaches based on available data to help solve clinical problems. Within these objectives, all projects on the current grant are organized into two specific AIMS: 1. To prevent organ destruction. This includes not only immunologic manipulations designed to prevent rejection and immunologic graft loss, but also those designed to prevent nonimmunologic graft loss, to prolong recipient survival, and to modify or control drug toxicity and recurrent disease. 2. To maximize rehabilitation. The focus here is on minimizing complications and maximizing quality of life.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK013083-43
Application #
8326694
Study Section
Special Emphasis Panel (ZDK1-GRB-R (J1))
Program Officer
Flessner, Michael Francis
Project Start
1998-02-21
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
43
Fiscal Year
2012
Total Cost
$1,286,034
Indirect Cost
$430,073
Name
University of Minnesota Twin Cities
Department
Surgery
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Vezina, Heather E; Brundage, Richard C; Balfour Jr, Henry H (2014) Population pharmacokinetics of valganciclovir prophylaxis in paediatric and adult solid organ transplant recipients. Br J Clin Pharmacol 78:343-52
Balfour Jr, Henry H (2014) Editorial commentary: Genetics and infectious mononucleosis. Clin Infect Dis 58:1690-1
Nevins, Thomas E; Robiner, William N; Thomas, William (2014) Predictive patterns of early medication adherence in renal transplantation. Transplantation 98:878-84
Balfour Jr, Henry H (2014) Progress, prospects, and problems in Epstein-Barr virus vaccine development. Curr Opin Virol 6:1-5
Verghese, Priya S; Dunn, Ty B; Chinnakotla, Srinath et al. (2014) Calcineurin inhibitors in HLA-identical living related donor kidney transplantation. Nephrol Dial Transplant 29:209-18
Suszynski, Thomas M; Rizzari, Michael D; Gillingham, Kristen J et al. (2013) Antihypertensive pharmacotherapy and long-term outcomes in pediatric kidney transplantation. Clin Transplant 27:472-80
Najafian, Behzad; Mauer, Michael (2013) Predilection of segmental glomerulosclerosis lesions for the glomerulotubular junction area in type 1 diabetic patients: a novel mapping method. PLoS One 8:e69253
Mauer, Michael; Fioretto, Paola (2013) Pancreas transplantation and reversal of diabetic nephropathy lesions. Med Clin North Am 97:109-14
Ponchiardi, Cecilia; Mauer, Michael; Najafian, Behzad (2013) Temporal profile of diabetic nephropathy pathologic changes. Curr Diab Rep 13:592-9
Suszynski, T M; Gillingham, K J; Rizzari, M D et al. (2013) Prospective randomized trial of maintenance immunosuppression with rapid discontinuation of prednisone in adult kidney transplantation. Am J Transplant 13:961-70

Showing the most recent 10 out of 319 publications