instmctions): The Mouse Model Core (Core A) is an established Core facility of the Program Project that has the overall goal to enhance the research endeavors of the Units and facilitate the conduct of research by individual Research Units that require support for conducting experiments involving mice, and in mouse breeding and maintenance. The Core offers the following high-quality services in a cost-effective manner to Program investigators: 1. Breeding and maintenance of normal and mutant mice a. Acquisition and basic maintenance of normal and mutant mouse strains b. Design and implementation of breeding schemes involving normal and mutant mice c. Assistance in generating new mutant mice 2. Assistance in conducting mouse experiments a. Infections with enteric pathogens b. Induction and analysis of experimental colitis models c. Irradiation and bone marrow transplantation d. Collection of tissues, blood and fecal samples e. Preparation and use of ligated intestinal loops 3. Administrative and training support for mouse studies a. Administrative assistance in acquiring and transferring animals b. Support in preparation and submission of animal protocols, and compliance procedures c. Training in conducting animal studies The Mouse Model Core is fully equipped and has an experienced animal technician to provide the offered services at the highest quality in a cost-effective manner. The Core interacts closely with individual Program investigators and the other Cores to assist in achieving the scientific objectives of the Program.
Animal models are critical for immunological research because the complexity of the immune system can only be adequately investigated in the normal biological context. Mice are the preferred model for the studies, since they are genetically closely related to humans, are readily amenable to different experimental designs, and many genetically engineered strains and immunological reagents are commonly available.
|Bertin, S; Lozano-Ruiz, B; Bachiller, V et al. (2015) Dual-specificity phosphatase 6 regulates CD4+ T-cell functions and restrains spontaneous colitis in IL-10-deficient mice. Mucosal Immunol 8:505-15|
|Vicente-Suarez, I; Larange, A; Reardon, C et al. (2015) Unique lamina propria stromal cells imprint the functional phenotype of mucosal dendritic cells. Mucosal Immunol 8:141-51|
|Spatola, B N; Kaukinen, K; Collin, P et al. (2014) Persistence of elevated deamidated gliadin peptide antibodies on a gluten-free diet indicates nonresponsive coeliac disease. Aliment Pharmacol Ther 39:407-17|
|Debnath, Anjan; Shahinas, Dea; Bryant, Clifford et al. (2014) Hsp90 inhibitors as new leads to target parasitic diarrheal diseases. Antimicrob Agents Chemother 58:4138-44|
|Dann, Sara M; Le, Christine; Choudhury, Barun K et al. (2014) Attenuation of intestinal inflammation in interleukin-10-deficient mice infected with Citrobacter rodentium. Infect Immun 82:1949-58|
|Meehan, T F; Witherden, D A; Kim, C-H et al. (2014) Protection against colitis by CD100-dependent modulation of intraepithelial ?? T lymphocyte function. Mucosal Immunol 7:134-42|
|Bertin, Samuel; Aoki-Nonaka, Yukari; de Jong, Petrus Rudolf et al. (2014) The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4? T cells. Nat Immunol 15:1055-63|
|de Jong, Petrus R; Takahashi, Naoki; Harris, Alexandra R et al. (2014) Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis. J Clin Invest 124:3793-806|
|González-Navajas, José M; Corr, Mary P; Raz, Eyal (2014) The immediate protective response to microbial challenge. Eur J Immunol 44:2536-49|
|Barbero, Erika M; McNally, Shawna L; Donohue, Michael C et al. (2014) Barriers impeding serologic screening for celiac disease in clinically high-prevalence populations. BMC Gastroenterol 14:42|
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