CORE Awill serve as the Administrative and Informatics Core for the Program ProjectGrant. It will assistPPG investigators and Coreleaders by providingnecessary planning and developmentand prepare annualgrant reports. CoreAwill plan and run monthlyPPGresearch rounds,meetings of the InternalSteeringCommittee, and the External Advisory Committee (EAC). CoreAwill work with the EAC to obtain and disseminate evaluations of the program. The core will also meet regulatory requirements as established by federal and state governments. CoreAwill also assist with the preparation of competingand non-competing grant renewals necessary for maintenanceof the PPG. It will provided help with budgets, animalprotocols, human use requirements, toxic chemical information, homelandsecurity requirments, personnelissues, etc. Core Awill provide assistance with travel for seminar and workshop speakers, EAC members, and PPGparticipants. CoreA will also run searches for replacement PPG staff and post-doctoral students as positionsare vacated. The Core will assist with relocation issues for staff, students and post-docs that take positionsin the Program. The core will help with visa and immigration requirements to see that PPGstaff and students remain in compliancewith federal requirements. The Core will provide statistical consultingfor planning of experimentalprotocols and analysis of data.

Public Health Relevance

The PPG is investigating the structure of the neuromuscular apparatus of the Gl tract. This topic is relevant to clinical problems faced by millions of patients. Core A provides centralized administrative support to the investigative team to increase their efficiency. Core A also provides statistical consulting to increase the power of experiments, reduce the use of animals, and increase validity of the findings.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Research Program Projects (P01)
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Special Emphasis Panel (ZDK1-GRB-9)
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University of Nevada Reno
United States
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Sanders, Kenton M; Salter, Anna K; Hennig, Grant W et al. (2014) Responses to enteric motor neurons in the gastric fundus of mice with reduced intramuscular interstitial cells of cajal. J Neurogastroenterol Motil 20:171-84
Zheng, Haifeng; Park, Kyung Sik; Koh, Sang Don et al. (2014) Expression and function of a T-type Ca2+ conductance in interstitial cells of Cajal of the murine small intestine. Am J Physiol Cell Physiol 306:C705-13
McCann, Conor J; Hwang, Sung-Jin; Hennig, Grant W et al. (2014) Bone Marrow Derived Kit-positive Cells Colonize the Gut but Fail to Restore Pacemaker Function in Intestines Lacking Interstitial Cells of Cajal. J Neurogastroenterol Motil 20:326-37
Durnin, Leonie; Hwang, Sung Jin; Kurahashi, Masaaki et al. (2014) Uridine adenosine tetraphosphate is a novel neurogenic P2Y1 receptor activator in the gut. Proc Natl Acad Sci U S A 111:15821-6
Okamoto, T; Barton, M J; Hennig, G W et al. (2014) Extensive projections of myenteric serotonergic neurons suggest they comprise the central processing unit in the colon. Neurogastroenterol Motil 26:556-70
Drumm, Bernard T; Koh, Sang Don; Andersson, Karl-Erik et al. (2014) Calcium signalling in Cajal-like interstitial cells of the lower urinary tract. Nat Rev Urol 11:555-64
Mutafova-Yambolieva, Violeta N; Durnin, Leonie (2014) The purinergic neurotransmitter revisited: a single substance or multiple players? Pharmacol Ther 144:162-91
Sanders, Kenton M; Ward, Sean M; Koh, Sang Don (2014) Interstitial cells: regulators of smooth muscle function. Physiol Rev 94:859-907
Kurahashi, Masaaki; Nakano, Yasuko; Peri, Lauren E et al. (2013) A novel population of subepithelial platelet-derived growth factor receptor *-positive cells in the mouse and human colon. Am J Physiol Gastrointest Liver Physiol 304:G823-34
Keef, K D; Saxton, S N; McDowall, R A et al. (2013) Functional role of vasoactive intestinal polypeptide in inhibitory motor innervation in the mouse internal anal sphincter. J Physiol 591:1489-506

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