In our experience the main challenge seen in administering a multi-institutional Program such as ours is in keeping the individual teams on track, working continually toward completion of shared goals and objectives. We have had tremendous success at this. The key to what we have been able to accomplish distills down to several essential elements. Our investigators are skilled at collaborative science, we work extremely well together, as individuals we are dedicated to the overall success of the group, and we build by keeping communication at a very high level. This is successful team science facilitated by strong leadership. We are in Year-19 of this PPG. Over this time, we have enjoyed remarkable stability among the participating institutions and our key personnel. The current proposal includes two Projects (Projects 1 &2) at the APL- University of Washington with subcontracts to CalTech, Oxford University and the University of Illinois, and a Project (Project 3) at Indiana University with a subcontract to IU-Health. The Administrative Core (Core A) will be at the APL-UW, and the Statistical Core (Core B) will be at Indiana University. This competitive renewal application marks a change in leadership and sponsoring institution for the PPG. The Applied Physics Laboratory at the University of Washington is a major research and development center with approximately 300 staff and with over 200 scientists and engineers, including 100 who hold PhDs. In 2012, income from competitive extramural grants and contracts exceeded $76.5 million. This year in advance of the renewal, APL has provided equipment critical to the proposed research and to be shared by all the Projects of the PPG, including one of the $100,000 ultrasound platforms which the entire PPG proposes to share. APL also provided half the funds to pay for the Dornier Compact-S shock wave lithotripter/C-arm used in PPG research. Michael R. Bailey, PhD will serve as Program Director. Dr. Bailey joined the PPG in 1996 as Co- Investigator and succeeded Dr. Lawrence Crum as PL in 2004. Dr. Bailey is Senior Principal Engineer (equivalent to Professor) at the APL with joint faculty appointments in the Departments of Mechanical Engineering and Urology at UW. He holds a strong portfolio of extramural funding and his current active grant support as PI (P01-DK43881, R01-DK92197, NASA/NSBRI SMST3402 and SMST0002) generates over $1.25 million in annual direct costs. APL and Dr. Bailey are eminently qualified to direct this Program.
The Specific Aims of the Administrative Core are to provide fiscal and scientific leadership for the Program Project. In matters of fiscal responsibility, Core A will organize yearly negotiation and preparation of subcontracts and will maintain accounting records for the Program. Core A will coordinate the scientific activities of the team, monitoring the progress of each Project, and overseeing productivity and attainment of research goals. Core A will also organize the quarterly and semi-annual meetings of the Projects and Cores to facilitate communication and the sharing of data among the Project Leads (PL's) and key personnel. In addition, Core A will serve as liaison between the PPG investigators and the External Advisory Committee and Board of Directors with the goal of gathering unbiased, constructive advice to assist the PPG team in staying on track and meeting our objectives.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
2P01DK043881-20
Application #
8740042
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2014-09-16
Budget End
2015-06-30
Support Year
20
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
City
Seattle
State
WA
Country
United States
Zip Code
98195
Janssen, Karmon M; Brand, Timothy C; Bailey, Michael R et al. (2018) Effect of Stone Size and Composition on Ultrasonic Propulsion Ex Vivo. Urology 111:225-229
Simon, Julianna C; Sapozhnikov, Oleg A; Kreider, Wayne et al. (2018) The role of trapped bubbles in kidney stone detection with the color Doppler ultrasound twinkling artifact. Phys Med Biol 63:025011
Matula, Thomas J; Sapozhnikov, Oleg A; Ostrovsky, Lev A et al. (2018) Ultrasound-based cell sorting with microbubbles: A feasibility study. J Acoust Soc Am 144:41
Williams Jr, James C; Borofsky, Michael S; Bledsoe, Sharon B et al. (2018) Papillary Ductal Plugging is a Mechanism for Early Stone Retention in Brushite Stone Disease. J Urol 199:186-192
Sapozhnikov, Oleg; Nikolaeva, Anastasiia; Bailey, Michael (2018) The effect of shear waves in an elastic sphere on the radiation force from a quasi-Gaussian beam. Proc Meet Acoust 32:
Zwaschka, Theresa A; Ahn, Justin S; Cunitz, Bryan W et al. (2018) Combined Burst Wave Lithotripsy and Ultrasonic Propulsion for Improved Urinary Stone Fragmentation. J Endourol 32:344-349
Connors, Bret A; Schaefer, Ray B; Gallagher, John J et al. (2018) Preliminary Report on Stone Breakage and Lesion Size Produced by a New Extracorporeal Electrohydraulic (Sparker Array) Discharge Device. Urology 116:213-217
Dai, Jessica C; Dunmire, Barbrina; Sternberg, Kevan M et al. (2018) Retrospective comparison of measured stone size and posterior acoustic shadow width in clinical ultrasound images. World J Urol 36:727-732
Rosnitskiy, Pavel B; Yuldashev, Petr V; Sapozhnikov, Oleg A et al. (2017) Design of HIFU Transducers for Generating Specified Nonlinear Ultrasound Fields. IEEE Trans Ultrason Ferroelectr Freq Control 64:374-390
Li, Guangyan; Connors, Bret A; Schaefer, Ray B et al. (2017) Evaluation of an experimental electrohydraulic discharge device for extracorporeal shock wave lithotripsy: Pressure field of sparker array. J Acoust Soc Am 142:3147

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