The Administration Core is the umbrella organization for the Program Project. Under the Direction of Dr. Stephan Targan, the Administration Core provides scientific guidance and disseminates current information regarding research in the inflammatory bowel diseases. The Program Project Manager provides fiscal and budgetary support as well as ensures that human subject and animal use protocols are current. The Administration Core interacts as liaison between the National Institutes of Health, Cedars-Sinai Medical Center, the University of California at Los Angeles, and the La Jolla Institute for Allergy and Immunology. The Administration Core organizes administrative/scientific meetings of the Program Project investigators. Logistical arrangements for the Scientific Advisory Committee and the organization of symposia are also provided. The Administration Core Is the first source of contact with the Program Project advisors. Administration Core co-Director, Dr. Jerome I. Rotter is responsible for the function of the Program Project in the absence of Dr. Targan.
Inflammatory bowel diseases affect more than one million Americans and the incidence is rising. The work described in the program project proposal will further understanding of the causes of these diseases and aid in the development of patient-specific therapies.
|Li, Dalin; Achkar, Jean-Paul; Haritunians, Talin et al. (2016) A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition. Gastroenterology 151:724-32|
|Taleban, Sasha; Li, Dalin; Targan, Stephan R et al. (2016) Ocular Manifestations in Inflammatory Bowel Disease Are Associated with Other Extra-intestinal Manifestations, Gender, and Genes Implicated in Other Immune-related Traits. J Crohns Colitis 10:43-9|
|van der Gracht, EsmÃ©; Zahner, Sonja; Kronenberg, Mitchell (2016) When Insult Is Added to Injury: Cross Talk between ILCs and Intestinal Epithelium in IBD. Mediators Inflamm 2016:9765238|
|Rivas, Manuel A; Graham, Daniel; Sulem, Patrick et al. (2016) A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis. Nat Commun 7:12342|
|Cleynen, Isabelle; Boucher, Gabrielle; Jostins, Luke et al. (2016) Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study. Lancet 387:156-67|
|Chu, Hiutung; Khosravi, Arya; Kusumawardhani, Indah P et al. (2016) Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science 352:1116-20|
|Guerrerio, Anthony L; Frischmeyer-Guerrerio, Pamela A; Huang, Chengrui et al. (2016) Increased Prevalence of Inflammatory Bowel Disease in Patients with Mutations in Genes Encoding the Receptor Subunits for TGFÎ². Inflamm Bowel Dis 22:2058-62|
|Chuang, Ling-Shiang; Villaverde, Nicole; Hui, Ken Y et al. (2016) A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF. Gastroenterology 151:710-723.e2|
|Hoang-Yen Tran, D; Hoang-Ngoc Tran, D; Mattai, S A et al. (2016) Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor. Int J Obes (Lond) 40:1424-34|
|Kopylov, Uri; Boucher, Gabrielle; Waterman, Matti et al. (2016) Genetic Predictors of Benign Course of Ulcerative Colitis-A North American Inflammatory Bowel Disease Genetics Consortium Study. Inflamm Bowel Dis 22:2311-6|
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