of computer facilities is in need of updating. Presumably the PowerMac is no longer in use. 3. Qualifications of the Program Director and other Personnel: Strengths * The Director and other personnel seem very well qualified to direct and run this core. 4. Appropriateness of the Timetable: Strengths * Approach to taking on work seems fine for this type of core. Weaknesses * No specific timetable described (or needed).

Public Health Relevance

Our program project addresses the fundamental mechanisms in insulin resistance that accompanies diabetes and metabolic syndrome. With approximately one third of the US population considered obese, including an increasing proportion of children, these two diseases have reached epidemic proportions. Thus, our multi-faceted approach to address the underlying molecular mechanisms driving the assembly and dissociation of protein scaffolds during insulin resistance/insufficiency will provide novel insights into the organization of signaling networks that regulate metabolic syndrome and has the potential to identify novel targets for therapeutic intervention.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
2P01DK054441-14A1
Application #
8475922
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (J1))
Program Officer
Sechi, Salvatore
Project Start
1998-12-15
Project End
2018-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
14
Fiscal Year
2013
Total Cost
$1,749,619
Indirect Cost
$508,752
Name
University of California San Diego
Department
Pharmacology
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
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