of computer facilities is in need of updating. Presumably the PowerMac is no longer in use. 3. Qualifications of the Program Director and other Personnel: Strengths * The Director and other personnel seem very well qualified to direct and run this core. 4. Appropriateness of the Timetable: Strengths * Approach to taking on work seems fine for this type of core. Weaknesses * No specific timetable described (or needed).
Our program project addresses the fundamental mechanisms in insulin resistance that accompanies diabetes and metabolic syndrome. With approximately one third of the US population considered obese, including an increasing proportion of children, these two diseases have reached epidemic proportions. Thus, our multi-faceted approach to address the underlying molecular mechanisms driving the assembly and dissociation of protein scaffolds during insulin resistance/insufficiency will provide novel insights into the organization of signaling networks that regulate metabolic syndrome and has the potential to identify novel targets for therapeutic intervention.
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|Nygren, Patrick J; Scott, John D (2016) Regulation of the phosphatase PP2B by protein-protein interactions. Biochem Soc Trans 44:1313-1319|
|Bjerregaard-Andersen, Kaare; Ã˜stensen, Ellen; Scott, John D et al. (2016) Malonate in the nucleotide-binding site traps human AKAP18Î³/Î´ in a novel conformational state. Acta Crystallogr F Struct Biol Commun 72:591-7|
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|Nieves-CintrÃ³n, Madeline; Hirenallur-Shanthappa, Dinesh; Nygren, Patrick J et al. (2016) AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction. Cell Signal 28:733-40|
|Kountz, Timothy S; Lee, Kyung-Soon; Aggarwal-Howarth, Stacey et al. (2016) Endogenous N-terminal Domain Cleavage Modulates Î±1D-Adrenergic Receptor Pharmacodynamics. J Biol Chem 291:18210-21|
|Cordes, Thekla; Wallace, Martina; Michelucci, Alessandro et al. (2016) Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels. J Biol Chem 291:14274-84|
|Riggle, Kevin M; Riehle, Kimberly J; Kenerson, Heidi L et al. (2016) Enhanced cAMP-stimulated protein kinase A activity in human fibrolamellar hepatocellular carcinoma. Pediatr Res 80:110-8|
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