The project focuses on the concept that chronic activation of infiammatory pathways and that the macro- phage/adipocyte nexus provides a l

Public Health Relevance

Insulin resistance is a key feature in Type 2 diabetes mellitus, and macrophage mediated chronic tissue inflammation is an Important etiologic component in this insulin resistant state. This project should elucidate novel actions of anti-inflammatory signaling, and reveal the specific mechanisms underlying the anti-inflam- matory and insulin sensitizing effects of GPR120/omega 3 fatty acids. An improved basic understanding of these cellular events has the potential to lead to new therapeutic opportunities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
2P01DK054441-14A1
Application #
8573098
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (J1))
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
14
Fiscal Year
2013
Total Cost
$348,750
Indirect Cost
$123,750
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
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