The Administrative Core, directed by Dr. Susan Taylor with Dr. Alexandra Newton serving as Assistant Director, will perform all of the administrative functions require by the program. To achieve this we have established a Project Manager, Grace Liu, who will work closely with Drs. Taylor and Newton, with each PI, and with each of the core leaders. This will include accounting, organization of scientific interactions, organization and coordination of monthly meetings, organization and coordination of invited speakers to the UCSD campus, organization and coordination of workshops in San Diego, and preparation of manuscripts and progress reports. She will also manage the budgets and track ordering and spending. All of the investigators are on the UCSD campus except for Dr. John Scott who has recently moved from the Vollum Institute in Portland, Oregon, to the Department of Pharmacology at the University of Washington where he holds the Edwin G. Krebs Chair. A major goal for this next granting period will be to organize biennial meetings that are held alternatively in San Diego and Seattle. There is historically a strong link between the two campuses in the area of signal transduction, and we would like to re-establish this axis. Planning an implementation of these meetings would also come under the purview of the Administrative Core. We also will have access to the San Diego Supercomputer Center and to Cal-IT2, which provide important key resources for our cores and for our bioinformatics specialist who will be funded in part from matching funds from the university. This individual will interface closely with Cores A. B. and C and will link many of the structural, biochemical, mass spectrometry and imaging components of the program. These are all data intensive endeavors. In addition, he/she will interface with other computational resources at UCSD such as the Protein Data Bank, the National Center for Microscopy and Imaging Research (NICMIR) headed by Dr. Mark Ellisman who also is the director of Core B, and the Phenotyping Core facility that is funded by NIDDK.

Public Health Relevance

Given the diversity of our team and the interdisciplinary nature of the research that we are doing it is essential to have a central coordinator for our PPG. Planning of workshops and coordination between research teams requires strong central leadership that goes beyond any one project or core. The smooth integration of all the projects and cores is a major cornerstone for our success.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
2P01DK054441-14A1
Application #
8573103
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (J1))
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
14
Fiscal Year
2013
Total Cost
$27,902
Indirect Cost
$9,901
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Baeza-Raja, Bernat; Sachs, Benjamin D; Li, Pingping et al. (2016) p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Rep 14:255-68
Cherry, Allison E; Haas, Brian R; Naydenov, Alipi V et al. (2016) ST-11: A New Brain-Penetrant Microtubule-Destabilizing Agent with Therapeutic Potential for Glioblastoma Multiforme. Mol Cancer Ther 15:2018-29
Turnham, Rigney E; Scott, John D (2016) Protein kinase A catalytic subunit isoform PRKACA; History, function and physiology. Gene 577:101-8
Nygren, Patrick J; Scott, John D (2016) Regulation of the phosphatase PP2B by protein-protein interactions. Biochem Soc Trans 44:1313-1319
Bjerregaard-Andersen, Kaare; Østensen, Ellen; Scott, John D et al. (2016) Malonate in the nucleotide-binding site traps human AKAP18γ/δ in a novel conformational state. Acta Crystallogr F Struct Biol Commun 72:591-7
Whiting, Jennifer L; Ogier, Leah; Forbush, Katherine A et al. (2016) AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption. Proc Natl Acad Sci U S A 113:E4328-37
Nieves-Cintrón, Madeline; Hirenallur-Shanthappa, Dinesh; Nygren, Patrick J et al. (2016) AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction. Cell Signal 28:733-40
Kountz, Timothy S; Lee, Kyung-Soon; Aggarwal-Howarth, Stacey et al. (2016) Endogenous N-terminal Domain Cleavage Modulates α1D-Adrenergic Receptor Pharmacodynamics. J Biol Chem 291:18210-21
Cordes, Thekla; Wallace, Martina; Michelucci, Alessandro et al. (2016) Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels. J Biol Chem 291:14274-84
Riggle, Kevin M; Riehle, Kimberly J; Kenerson, Heidi L et al. (2016) Enhanced cAMP-stimulated protein kinase A activity in human fibrolamellar hepatocellular carcinoma. Pediatr Res 80:110-8

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