of computer facilities is in need of updating. Presumably the PowerMac is no longer in use. 3. Qualifications of the Program Director and other Personnel: Strengths * The Director and other personnel seem very well qualified to direct and run this core. 4. Appropriateness of the Timetable: Strengths * Approach to taking on work seems fine for this type of core. Weaknesses * No specific timetable described (or needed).

Public Health Relevance

Our program project addresses the fundamental mechanisms in insulin resistance that accompanies diabetes and metabolic syndrome. With approximately one third of the US population considered obese, including an increasing proportion of children, these two diseases have reached epidemic proportions. Thus, our multi-faceted approach to address the underlying molecular mechanisms driving the assembly and dissociation of protein scaffolds during insulin resistance/insufficiency will provide novel insights into the organization of signaling networks that regulate metabolic syndrome and has the potential to identify novel targets for therapeutic intervention.

National Institute of Health (NIH)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Sechi, Salvatore
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Diego
Schools of Medicine
La Jolla
United States
Zip Code
Cone, Angela C; Cavin, Gabriel; Ambrosi, Cinzia et al. (2014) Protein kinase C?-mediated phosphorylation of Connexin43 gap junction channels causes movement within gap junctions followed by vesicle internalization and protein degradation. J Biol Chem 289:8781-98
Kunkel, Maya T; Newton, Alexandra C (2014) Imaging kinase activity at protein scaffolds. Methods Mol Biol 1071:129-37
Suh, Jae Myoung; Jonker, Johan W; Ahmadian, Maryam et al. (2014) Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature 513:436-9
McNelis, Joanne C; Olefsky, Jerrold M (2014) Macrophages, immunity, and metabolic disease. Immunity 41:36-48
Lopez, Ana D; Kayali, Ayse G; Hayek, Alberto et al. (2014) Isolation, culture, and imaging of human fetal pancreatic cell clusters. J Vis Exp :
Dowding, J M; Song, W; Bossy, K et al. (2014) Cerium oxide nanoparticles protect against A?-induced mitochondrial fragmentation and neuronal cell death. Cell Death Differ 21:1622-32
Matt, Ulrich; Sharif, Omar; Martins, Rui et al. (2013) WAVE1 mediates suppression of phagocytosis by phospholipid-derived DAMPs. J Clin Invest 123:3014-24
Barkho, Sulyman; Pierce, Levi C T; McGlone, Maria L et al. (2013) Distal loop flexibility of a regulatory domain modulates dynamics and activity of C-terminal SRC kinase (csk). PLoS Comput Biol 9:e1003188
Wu-Zhang, Alyssa X; Newton, Alexandra C (2013) Protein kinase C pharmacology: refining the toolbox. Biochem J 452:195-209
Wiley, Sandra E; Andreyev, Alexander Y; Divakaruni, Ajit S et al. (2013) Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis. EMBO Mol Med 5:904-18

Showing the most recent 10 out of 142 publications