The remarkable progress that has recently been made in mammalian genetics has been significantly enabled by the development of resources and techniques for efficient genomic analysis. These resources, including highly polymorphic and easily scored genetic markers, large insert clone libraries, genetic mapping panels, and bioinformatics technology, will be relevant for a variety of applications in the individual Projects described as part of this Program. Of particular importance will be the pursuit of genome-wide genotype analysis in the mouse, and gene mapping studies in a number of vertebrate systems. Our laboratory has a great deal of experience in these technologies and will be able to support this Program Project in all aspects of genome analysis. Furthermore, this Genomics Core will have at its disposal sophisticated instrumentation for these studies (including an automated DNA sequencer, robotic workstation, and extensive computing capacity) that have been established as part of a commitment by the Brigham and Women?s Hospital to support state-of-the-art genetic technology.
| Drummond, Iain A (2011) Polycystins, focal adhesions and extracellular matrix interactions. Biochim Biophys Acta 1812:1322-6 |
| Mangos, Steve; Lam, Pui-ying; Zhao, Angela et al. (2010) The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation. Dis Model Mech 3:354-65 |
| Moller, Clemens C; Mangos, Steve; Drummond, Iain A et al. (2008) Expression of trpC1 and trpC6 orthologs in zebrafish. Gene Expr Patterns 8:291-6 |
| Mangos, Steve; Liu, Yan; Drummond, Iain A (2007) Dynamic expression of the osmosensory channel trpv4 in multiple developing organs in zebrafish. Gene Expr Patterns 7:480-4 |
| Pathak, Narendra; Obara, Tomoko; Mangos, Steve et al. (2007) The zebrafish fleer gene encodes an essential regulator of cilia tubulin polyglutamylation. Mol Biol Cell 18:4353-64 |
| Obara, Tomoko; Mangos, Steven; Liu, Yan et al. (2006) Polycystin-2 immunolocalization and function in zebrafish. J Am Soc Nephrol 17:2706-18 |
| Kramer-Zucker, Albrecht G; Olale, Felix; Haycraft, Courtney J et al. (2005) Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis. Development 132:1907-21 |
| Drummond, Iain A (2005) Kidney development and disease in the zebrafish. J Am Soc Nephrol 16:299-304 |
| Li, Zhixing; Stuart, Robert O; Eraly, Satish A et al. (2003) Debt91, a putative zinc finger protein differentially expressed during epithelial morphogenesis. Biochem Biophys Res Commun 306:623-8 |
| Xu, G Mark; Gonzalez-Perrett, Silvia; Essafi, Makram et al. (2003) Polycystin-1 activates and stabilizes the polycystin-2 channel. J Biol Chem 278:1457-62 |
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