The objective of Core B is to provide histopathology support, both technical and interpretative, for Projects 1 through 4. For Project 1, Core B will process murine tissues for light microscopic analysis, for laser capture microdissection and for electron microscopy. Scoring of murine tissues for disease severity will be performed blindly. For Project 2, core B will provide diagnostic expertise to classify human renal biopsies as HIVAN vs. non-HIVAN renal disease by integration of light microscopic, immunofluorescence and electron microscopic findings in blinded fashion. For Project 3, novel reagents to gene products of interest will be screened on normal and diseased human renal tissue and murine tissues by immunocytochemistry and immunoelectronmicroscopy. For Project 4, immunohistochemistry for proteins regulated by Nef signaling pathways will be performed on murine and human renal tissues.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK056492-14
Application #
8566349
Study Section
Special Emphasis Panel (ZDK1-GRB-D (J1))
Project Start
1999-09-30
Project End
2015-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
14
Fiscal Year
2012
Total Cost
$102,552
Indirect Cost
$21,846
Name
Baylor College of Medicine
Department
Type
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
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