Abstract

The objective of the Clinical Core (Core C) is to provide biologic specimens and corresponding clinical and laboratory data from well-characterized patients with HIV infection and kidney disease and from relevant controls to support the work proposed in this Program Project. The Clinical Core will provide kidney tissue, urine, blood, and stool specimens to support research into the long-term consequences of chronic HIV infection in the kidney, including the role of HIV infection in promoting kidney disease and the potential for the kidney to serve as a reservoir for the virus.

Public Health Relevance

The proposed research has important implications for the health of individuals living with chronic HIV infection. The Clinical Core will support research to characterize the contribution of chronic HIV infection to the increased risk of kidney disease in HIV infected individuals. This research will be particularly relevant to African- Americans, who have a disproportionate burden of both HIV infection and chronic kidney disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK056492-18
Application #
9481279
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2018-05-01
Budget End
2019-04-30
Support Year
18
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Type
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Chan, Lili; Asriel, Benjamin; Eaton, Ellen F et al. (2018) Potential kidney toxicity from the antiviral drug tenofovir: new indications, new formulations, and a new prodrug. Curr Opin Nephrol Hypertens 27:102-112
Swanepoel, Charles R; Atta, Mohamed G; D'Agati, Vivette D et al. (2018) Kidney disease in the setting of HIV infection: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int 93:545-559
Zhong, Fang; Chen, Zhaohong; Zhang, Liwen et al. (2018) Tyro3 is a podocyte protective factor in glomerular disease. JCI Insight 3:
Palau, Laura; Menez, Steven; Rodriguez-Sanchez, Javier et al. (2018) HIV-associated nephropathy: links, risks and management. HIV AIDS (Auckl) 10:73-81
Zhong, Fang; Chen, Haibing; Xie, Yifan et al. (2018) Protein S Protects against Podocyte Injury in Diabetic Nephropathy. J Am Soc Nephrol 29:1397-1410
Hong, Quan; Zhang, Lu; Das, Bhaskar et al. (2018) Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury. Kidney Int 93:1330-1343
Fu, Jia; Wei, Chengguo; Zhang, Weijia et al. (2018) Gene expression profiles of glomerular endothelial cells support their role in the glomerulopathy of diabetic mice. Kidney Int 94:326-345
Corona-Villalobos, Celia P; Shlipak, Michael G; Tin, Adrienne et al. (2017) Predictors of Acute Renal Injury Study (PARIS) among HIV-positive individuals: design and methods. BMC Nephrol 18:289
Gu, Xiangchen; Mallipattu, Sandeep K; Guo, Yiqing et al. (2017) The loss of Krüppel-like factor 15 in Foxd1+ stromal cells exacerbates kidney fibrosis. Kidney Int 92:1178-1193
Wei, Chengguo; Li, Li; Menon, Madhav C et al. (2017) Genomic Analysis of Kidney Allograft Injury Identifies Hematopoietic Cell Kinase as a Key Driver of Renal Fibrosis. J Am Soc Nephrol 28:1385-1393

Showing the most recent 10 out of 111 publications