The Administrative Core serves the function of ensuring that the Program Project and all of its component parts function smoothly. The Administrative Core assures compliance with all policies and procedures pertaining to lab safety, including required environmental health and safety training for all laboratory employees, blood borne pathogens, tuberculosis and infection control, health care worker/Joint Committee on Accreditation of Hospitals general safety, and the overall lab safety plan. If there are any new employees or changes in requirements for any policies or procedures, the Administrative Core assures completion of the appropriate training and orientation. This core insures that all HIPPA rules and regulations are followed, and that Institutional Review Board regulations, forms and updates are complied with. Further, the clinic where many of our patients are seen must follow OSHA and Joint Committee on Accreditation of Hospitals guidelines. The Administrative Core assures proper completion and compliance with all animal rights and IACUC forms. There are day-to-day issues pertaining to publications, mailings, and the intake and output of supplies that fall under the general purview of the Administrative Core. The Administrative Core monitors the overall budget and the budget for each of the projects and cores for accurate accountability, to assure that personnel are appropriately compensated, and to ensure that there is adequate disbursement of funds for supplies and equipment as necessary.

Public Health Relevance

Core B provides centralized administrative support, human subjects policy, lab safety and animal welfare oversight to all 4 of the proposed research projects and Core A of the Program Project ANCA Glomerulonephritis: from Molecules to Man.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-R)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Chapel Hill
United States
Zip Code
Aybar, L T; McGregor, J G; Hogan, S L et al. (2015) Reduced CD5(+) CD24(hi) CD38(hi) and interleukin-10(+) regulatory B cells in active anti-neutrophil cytoplasmic autoantibody-associated vasculitis permit increased circulating autoantibodies. Clin Exp Immunol 180:178-88
Cao, Yali; Liu, Kuo; Tian, Zhigang et al. (2015) PTPN22 R620W polymorphism and ANCA disease risk in white populations: a metaanalysis. J Rheumatol 42:292-9
Jennette, J Charles; Falk, Ronald J (2014) B cell-mediated pathogenesis of ANCA-mediated vasculitis. Semin Immunopathol 36:327-38
Joy, Melanie S; Roberts, Brittney V; Wang, Jinzhao et al. (2014) A pilot study of leukocyte expression patterns for drug metabolizing enzyme and transporter transcripts in autoimmune glomerulonephritis. Int J Clin Pharmacol Ther 52:303-13
Jennette, J Charles; Falk, Ronald J (2014) Pathogenesis of antineutrophil cytoplasmic autoantibody-mediated disease. Nat Rev Rheumatol 10:463-73
Xiao, Hong; Dairaghi, Daniel J; Powers, Jay P et al. (2014) C5a receptor (CD88) blockade protects against MPO-ANCA GN. J Am Soc Nephrol 25:225-31
Geetha, Duvuru; Poulton, Caroline J; Hu, Yichun et al. (2014) Clinical characteristics and outcome of pauci-immune glomerulonephritis in African Americans. Semin Arthritis Rheum 43:778-83
Xiao, Hong; Ciavatta, Dominic; Aylor, David L et al. (2013) Genetically determined severity of anti-myeloperoxidase glomerulonephritis. Am J Pathol 182:1219-26
Jennette, J Charles (2013) Overview of the 2012 revised International Chapel Hill Consensus Conference nomenclature of vasculitides. Clin Exp Nephrol 17:603-6
Free, Meghan E; Bunch, Donna O'Dell; McGregor, Julie Anne et al. (2013) Patients with antineutrophil cytoplasmic antibody-associated vasculitis have defective Treg cell function exacerbated by the presence of a suppression-resistant effector cell population. Arthritis Rheum 65:1922-33

Showing the most recent 10 out of 42 publications