The Administrative Core serves the function of ensuring that the Program Project and all of its component parts function smoothly. The Administrative Core assures compliance with all policies and procedures pertaining to lab safety, including required environmental health and safety training for all laboratory employees, blood borne pathogens, tuberculosis and infection control, health care worker/Joint Committee on Accreditation of Hospitals general safety, and the overall lab safety plan. If there are any new employees or changes in requirements for any policies or procedures, the Administrative Core assures completion of the appropriate training and orientation. This core insures that all HIPPA rules and regulations are followed, and that Institutional Review Board regulations, forms and updates are complied with. Further, the clinic where many of our patients are seen must follow OSHA and Joint Committee on Accreditation of Hospitals guidelines. The Administrative Core assures proper completion and compliance with all animal rights and IACUC forms. There are day-to-day issues pertaining to publications, mailings, and the intake and output of supplies that fall under the general purview of the Administrative Core. The Administrative Core monitors the overall budget and the budget for each of the projects and cores for accurate accountability, to assure that personnel are appropriately compensated, and to ensure that there is adequate disbursement of funds for supplies and equipment as necessary.

Public Health Relevance

Core B provides centralized administrative support, human subjects policy, lab safety and animal welfare oversight to all 4 of the proposed research projects and Core A of the Program Project ANCA Glomerulonephritis: from Molecules to Man.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Research Program Projects (P01)
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Special Emphasis Panel (ZDK1-GRB-R)
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University of North Carolina Chapel Hill
Chapel Hill
United States
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Free, Meghan E; Falk, Ronald J (2016) The Search for a Biomarker of Relapse in ANCA-Associated Vasculitis. J Am Soc Nephrol 27:2551-3
Mariani, Laura H; Pendergraft 3rd, William F; Kretzler, Matthias (2016) Defining Glomerular Disease in Mechanistic Terms: Implementing an Integrative Biology Approach in Nephrology. Clin J Am Soc Nephrol 11:2054-2060
Yang, Jiajin; Ge, Heng; Poulton, Caroline J et al. (2016) Histone modification signature at myeloperoxidase and proteinase 3 in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis. Clin Epigenetics 8:85
Zhu, Meng-Lei; Bakhru, Pearl; Conley, Bridget et al. (2016) Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator. Nat Commun 7:11350
Rhee, Rennie L; Hogan, Susan L; Poulton, Caroline J et al. (2016) Trends in Long-Term Outcomes Among Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis With Renal Disease. Arthritis Rheumatol 68:1711-20
Thrasher, Bradly J; Hong, Lee Kyung; Whitmire, Jason K et al. (2016) Epigenetic Dysfunction in Turner Syndrome Immune Cells. Curr Allergy Asthma Rep 16:36
Bakhru, Pearl; Su, Maureen A (2016) Estrogen turns down ""the AIRE"". J Clin Invest 126:1239-41
Jennette, J Charles; Falk, Ronald J (2015) ANCAs are also antimonocyte cytoplasmic autoantibodies. Clin J Am Soc Nephrol 10:4-6
Pendergraft 3rd, William F; Badhwar, Anshul K; Preston, Gloria A (2015) Autoantigen complementarity and its contributions to hallmarks of autoimmune disease. J Theor Biol 375:88-94
Bunch, Donna O; Mendoza, Carmen E; Aybar, Lydia T et al. (2015) Gleaning relapse risk from B cell phenotype: decreased CD5+ B cells portend a shorter time to relapse after B cell depletion in patients with ANCA-associated vasculitis. Ann Rheum Dis 74:1784-6

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