Responsibility for administration of this program will reside in the Administrative core (Core C), directed by the overall PI of the program, Dr. Christopher B. Newgard, who will devote 5% of his time to this effort. He will be assisted in this role by James R. McCurdy, Business Manager of the Sarah W. Stedman Nutrition and Metabolism Center at Duke, and Ms. Brenda Aston, Chief Administrator of the Advanced Imaging Center at UTSW. This team will work closely with the project and core Pis in preparation of yearly progress reports, monitoring of personnel changes that occur during the course of the program, and oversight of the program budget, including yearly summaries of expenditures. Core C will also be responsible for assuring that the program is in compliance with institutional standards for human and animal research, including the timely submission of protocols to the relevant institutional review committees. A travel budget has been requested in Core C to allow four face-to-face meetings of the UTSW and Duke Pis per year, and for yearly meetings of the Scientific Advisory Board. Dr. Newgard and his staff will plan and coordinate those meetings. In the unlikely event that Dr. Newgard is rendered unable to fulfill his duties as Principal Investigator of this Program Project for any reason. Dr. Sherry will take full responsibility for completion of the program, and will work closely with the other investigators and senior administrative personnel at Duke and UTSWMC to ensure continued coordination of effort and delivery of the program milestones.

Public Health Relevance

The administrative core of this progam will provide oversight that ensures timely achievement of the core goals of the program, and will optimize communication between team members. It will also monitor all budgetary allocations, time commitment of key personnel, and progress reporting requirements.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Research Program Projects (P01)
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Special Emphasis Panel (ZDK1-GRB-N)
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Duke University
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Ren, Jimin; Sherry, A Dean; Malloy, Craig R (2017) Band inversion amplifies 31 P-31 P nuclear overhauser effects: Relaxation mechanism and dynamic behavior of ATP in the human brain by 31 P MRS at 7 T. Magn Reson Med 77:1409-1418
Newgard, Christopher B (2017) Metabolomics and Metabolic Diseases: Where Do We Stand? Cell Metab 25:43-56
Stöckli, Jacqueline; Fisher-Wellman, Kelsey H; Chaudhuri, Rima et al. (2017) Metabolomic analysis of insulin resistance across different mouse strains and diets. J Biol Chem 292:19135-19145
Ren, Jimin; Sherry, A Dean; Malloy, Craig R (2016) A simple approach to evaluate the kinetic rate constant for ATP synthesis in resting human skeletal muscle at 7 T. NMR Biomed 29:1240-8
Sun, Haipeng; Olson, Kristine C; Gao, Chen et al. (2016) Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure. Circulation 133:2038-49
Kucejova, Blanka; Duarte, Joao; Satapati, Santhosh et al. (2016) Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity. Cell Rep 16:508-519
Zhang, Wenwei; Bu, So Young; Mashek, Mara T et al. (2016) Integrated Regulation of Hepatic Lipid and Glucose Metabolism by Adipose Triacylglycerol Lipase and FoxO Proteins. Cell Rep 15:349-59
Jin, Eunsook S; Sherry, A Dean; Malloy, Craig R (2016) An Oral Load of [13C3]Glycerol and Blood NMR Analysis Detect Fatty Acid Esterification, Pentose Phosphate Pathway, and Glycerol Metabolism through the Tricarboxylic Acid Cycle in Human Liver. J Biol Chem 291:19031-41
Davies, Michael N; Kjalarsdottir, Lilja; Thompson, J Will et al. (2016) The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins. Cell Rep 14:243-54
Ren, Jimin; Sherry, A Dean; Malloy, Craig R (2016) Efficient (31) P band inversion transfer approach for measuring creatine kinase activity, ATP synthesis, and molecular dynamics in the human brain at 7 T. Magn Reson Med :

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