The experiments described within this proposal represent a new area of Invesfigation with implicafions for our understanding of A508-CFTR processing and trafficking. Identification ofthe critical pathways and establishment of their roles will pave the way forthe development of drugs to therapeutically alter the switching mechanisms that determine A508-CFTR's fate in Cystic Fibrosis. PROJECT/PERFORIVIANCE SITE(S) (if additional space is needed, use Project/Perfonnance Site Fonnat Page) Project/Performance

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK072084-07
Application #
8379310
Study Section
Special Emphasis Panel (ZDK1-GRB-8)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
7
Fiscal Year
2012
Total Cost
$368,863
Indirect Cost
$143,934
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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