Core A will carry out the following functions: 1) To provide the administrative and financial management of the Program Project. 2) Provide Pi's and Core Directors monthly understanding of expenditures and remaining financial obligations and fundmg available. Perform charge-back of use ofthe Cell Culture/Adenovirus and Lentivirus Core (3x/year) and Two- photon Microscopy and Zeiss 510/META, Confocal FRET/FRAP Imaging Core (3x/year), including use by PPG Investigators and other Hopkins users. 3) Maintain contact among PPG scientists via e-mail, informing them of weekly meetings, lectures of interest around Hopkins, NIH funding opportunities, etc. 4) To arrange for a yearly meeting of the Extemal Scientific Advisory Committee, bi-monthly meetings of the Litemal Executive Committee, yearly Scientific Retreat and weekly Research Conference and Joumal Club Meetings. 5) To organize research conferences and arrange for Program Enrichment by coordinating the visits ofthe Visiting Scientists who act as consultants and evaluate the science and interactions occurring in the Program Project. 6) Assist in^reparation of the Program Project Progress Report. 7) Help PPG members recruit post-doctoral fellows and technicians. 8) Help manage PPG service contracts. 9) Helpnegotiatepurchasingofequipment, animals, and supphes. 10) Serve as depository of Molecular Biology/Imaging/Proteomics software used by multiple PPG projects. 11) Develop and maintain databases for sharing of resources among PPG investigators including cells in culture, antibodies, cDNA's, vectors, Adenovirus constructs and Lentivirus shRNAs, techniques. 12) Help maintain Core C, Two-photon Microscopy and Zeiss 510/META Confocal Imaging Core, Web Page/Scheduling software.

Public Health Relevance

;PROJECT/PERFORIVIANCE SITE(S) (if additional space is needed, use Project/Perfonnance Site Fonnat Page Project/Performance

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK072084-07
Application #
8379311
Study Section
Special Emphasis Panel (ZDK1-GRB-8)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
7
Fiscal Year
2012
Total Cost
$125,510
Indirect Cost
$48,967
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Yu, Huimin; Hasan, Nesrin M; In, Julie G et al. (2017) The Contributions of Human Mini-Intestines to the Study of Intestinal Physiology and Pathophysiology. Annu Rev Physiol 79:291-312
Sarker, Rafiquel; Cha, Boyoung; Kovbasnjuk, Olga et al. (2017) Phosphorylation of NHE3-S719 regulates NHE3 activity through the formation of multiple signaling complexes. Mol Biol Cell 28:1754-1767
Qiang, Xiaoling; Liotta, Anthony S; Shiloach, Joseph et al. (2017) New melanocortin-like peptide of E. coli can suppress inflammation via the mammalian melanocortin-1 receptor (MC1R): possible endocrine-like function for microbes of the gut. NPJ Biofilms Microbiomes 3:31
Cha, Boyoung; Yang, Jianbo; Singh, Varsha et al. (2017) PDZ domain-dependent regulation of NHE3 protein by both internal Class II and C-terminal Class I PDZ-binding motifs. J Biol Chem 292:8279-8290
Foulke-Abel, Jennifer; In, Julie; Yin, Jianyi et al. (2016) Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology. Gastroenterology 150:638-649.e8
Gupta, Arnab; Schell, Michael J; Bhattacharjee, Ashima et al. (2016) Myosin Vb mediates Cu+ export in polarized hepatocytes. J Cell Sci 129:1179-89
Zachos, Nicholas C; Kovbasnjuk, Olga; Foulke-Abel, Jennifer et al. (2016) Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology. J Biol Chem 291:3759-66
Cebotaru, Liudmila; Liu, Qiangni; Yanda, Murali K et al. (2016) Inhibition of histone deacetylase 6 activity reduces cyst growth in polycystic kidney disease. Kidney Int 90:90-9
In, Julie; Foulke-Abel, Jennifer; Zachos, Nicholas C et al. (2016) Enterohemorrhagic Escherichia coli reduce mucus and intermicrovillar bridges in human stem cell-derived colonoids. Cell Mol Gastroenterol Hepatol 2:48-62.e3
Chen, Tiane; Kocinsky, Hetal S; Cha, Boyoung et al. (2015) Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites: identification of a multifunctional phosphorylation site. J Biol Chem 290:1952-65

Showing the most recent 10 out of 65 publications