Core B - Administrative Core: Organizational and Administrative Structure of the Program Project: Dr. Glass will be primarily responsible for decision-making and administration. Dr. Glass holds a primary appointment in the Department of Cellular and Molecular Medicine, Chaired by Dr. Donald Cleveland and a secondary appointment in the Department of Medicine, Chaired by Dr. Wulf Dillman. Dr. Olefsky and Dr. Rosenfeid will constitute an intemal Operating Committee to advise Dr. Glass on organizational and administrative Issues. As each Project and Core will be represented by this committee, the Operating Committee will also represent the chain of responsibility for execution of decisions. An external advisory group will be constituted to review the scientific program on an annual basis. The advisory group will be constituted to include expertise in insulin resistance, nuclear receptor action, inflammation and bioinformatics. The annual review will be performed in the context of a retreat in which all of the significant participants in this PPG will make detailed presentations describing progress and future directions.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Research Program Projects (P01)
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Special Emphasis Panel (ZDK1-GRB-6 (J1))
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University of California San Diego
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Li, Pingping; Liu, Shuainan; Lu, Min et al. (2016) Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell 167:973-984.e12
Glass, Christopher K; Natoli, Gioacchino (2016) Molecular control of activation and priming in macrophages. Nat Immunol 17:26-33
Baeza-Raja, Bernat; Sachs, Benjamin D; Li, Pingping et al. (2016) p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Rep 14:255-68
Oh, Da Young; Olefsky, Jerrold M (2016) G protein-coupled receptors as targets for anti-diabetic therapeutics. Nat Rev Drug Discov 15:161-72
Glass, Christopher K (2015) Genetic and genomic approaches to understanding macrophage identity and function. Arterioscler Thromb Vasc Biol 35:755-62
Li, Wenbo; Hu, Yiren; Oh, Soohwan et al. (2015) Condensin I and II Complexes License Full Estrogen Receptor α-Dependent Enhancer Activation. Mol Cell 59:188-202
Puc, Janusz; Kozbial, Piotr; Li, Wenbo et al. (2015) Ligand-dependent enhancer activation regulated by topoisomerase-I activity. Cell 160:367-80
Gorden, D Lee; Myers, David S; Ivanova, Pavlina T et al. (2015) Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. J Lipid Res 56:722-36
Kesby, James P; Kim, Jane J; Scadeng, Miriam et al. (2015) Spatial Cognition in Adult and Aged Mice Exposed to High-Fat Diet. PLoS One 10:e0140034
Fang, Sungsoon; Suh, Jae Myoung; Reilly, Shannon M et al. (2015) Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med 21:159-65

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