Abstract

Core B - Administrative Core: Organizational and Administrative Structure of the Program Project: Dr. Glass will be primarily responsible for decision-making and administration. Dr. Glass holds a primary appointment in the Department of Cellular and Molecular Medicine, Chaired by Dr. Donald Cleveland and a secondary appointment in the Department of Medicine, Chaired by Dr. Wulf Dillman. Dr. Olefsky and Dr. Rosenfeid will constitute an intemal Operating Committee to advise Dr. Glass on organizational and administrative Issues. As each Project and Core will be represented by this committee, the Operating Committee will also represent the chain of responsibility for execution of decisions. An external advisory group will be constituted to review the scientific program on an annual basis. The advisory group will be constituted to include expertise in insulin resistance, nuclear receptor action, inflammation and bioinformatics. The annual review will be performed in the context of a retreat in which all of the significant participants in this PPG will make detailed presentations describing progress and future directions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
2P01DK074868-06
Application #
8356002
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (J1))
Project Start
Project End
Budget Start
2012-05-25
Budget End
2013-04-30
Support Year
6
Fiscal Year
2012
Total Cost
$52,980
Indirect Cost
$18,781

  Institution

Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Riopel, Matthew; Seo, Jong Bae; Bandyopadhyay, Gautam K et al. (2018) Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function. J Clin Invest 128:1458-1470
Link, Verena M; Duttke, Sascha H; Chun, Hyun B et al. (2018) Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function. Cell 173:1796-1809.e17
Carlin, Aaron F; Vizcarra, Edward A; Branche, Emilie et al. (2018) Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages. Proc Natl Acad Sci U S A 115:E9172-E9181
Cardamone, Maria Dafne; Tanasa, Bogdan; Cederquist, Carly T et al. (2018) Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation. Mol Cell 69:757-772.e7
Fernandez, Marina O; Sharma, Shweta; Kim, Sun et al. (2017) Obese Neuronal PPAR? Knockout Mice Are Leptin Sensitive but Show Impaired Glucose Tolerance and Fertility. Endocrinology 158:121-133
Oishi, Yumiko; Spann, Nathanael J; Link, Verena M et al. (2017) SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism. Cell Metab 25:412-427
Ying, Wei; Wollam, Joshua; Ofrecio, Jachelle M et al. (2017) Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling. J Clin Invest 127:1019-1030
Johnson, Andrew M F; Hou, Shaocong; Li, Pingping (2017) Inflammation and insulin resistance: New targets encourage new thinking: Galectin-3 and LTB4 are pro-inflammatory molecules that can be targeted to restore insulin sensitivity. Bioessays 39:
Li, Pingping; Liu, Shuainan; Lu, Min et al. (2016) Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell 167:973-984.e12
Eichenfield, Dawn Z; Troutman, Ty Dale; Link, Verena M et al. (2016) Tissue damage drives co-localization of NF-?B, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages. Elife 5:

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