The Administrative Core provides strong centralized scientific and administrative leadership to the PPG, which facilitates synergistic interactions between the four projects and the other core and maintains the overall focus of the program project. Dr. Fabio Cominelli, Program Director, has primary responsibility for all aspects of the program. He will be assisted by the Executive Committee (project and core leaders), as well as the Internal and Extemal Advisory Boards. This core will oversee all annual budgets, monitor expenses and provide monthly statements of financial activities to the four projects and two cores. In addition, all program-related meetings will be scheduled through the core. These include the bi-weekly meeting of the Executive Committee to evaluate productivity, allocation of core usage, and program resources, discussions of future directions as well as presentation of research in progress, identification of problems and discussion of alternative approaches and solutions. The Adminstrative Core will also offer centralized biostatistical and manuscript support to all the projects. The enrichment program ofthe Administrative Core will arrange for the Annual Meeting of the Extemal Advisory Board as well as the Annual Intemational Scientific Workshop. In addition, generation of materials to be reviewed by the Advisory Boards will be handled through the Administrative Core. Finally, the Administrative Core will prepare, generate and assemble materials required for the annual progress reports and will insure that all additional NIH and institutional reporting requirements concerning PPG activities are fulfilled in a timely manner.

Public Health Relevance

CD affects more than 500,000 individuals in the US and incurs significant costs to society. Understanding the precise mechanisms and immune defects that cause the disease will allow us to develop better therapies and begin to develop a cure for this devastating disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK091222-03
Application #
8545829
Study Section
Special Emphasis Panel (ZDK1-GRB-6)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
3
Fiscal Year
2013
Total Cost
$92,560
Indirect Cost
$36,395
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
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Ryan, Sean O; Leal Jr, Sixto M; Abbott, Derek W et al. (2014) Mgat2 ablation in the myeloid lineage leads to defective glycoantigen T cell responses. Glycobiology 24:262-71
Goodman, W A; Garg, R R; Reuter, B K et al. (2014) Loss of estrogen-mediated immunoprotection underlies female gender bias in experimental Crohn's-like ileitis. Mucosal Immunol 7:1255-65
Bamias, Giorgos; Arseneau, Kristen O; Cominelli, Fabio (2014) Cytokines and mucosal immunity. Curr Opin Gastroenterol 30:547-52
Tigno-Aranjuez, Justine T; Benderitter, Pascal; Rombouts, Frederik et al. (2014) In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. J Biol Chem 289:29651-64
Corridoni, Daniele; Arseneau, Kristen O; Cominelli, Fabio (2014) Functional defects in NOD2 signaling in experimental and human Crohn disease. Gut Microbes 5:340-4
Corridoni, Daniele; Arseneau, Kristen O; Cominelli, Fabio (2014) Inflammatory bowel disease. Immunol Lett 161:231-5
Cavalcanti, Elisabetta; Vadrucci, Elisa; Delvecchio, Francesca Romana et al. (2014) Administration of reconstituted polyphenol oil bodies efficiently suppresses dendritic cell inflammatory pathways and acute intestinal inflammation. PLoS One 9:e88898
Goodman, Wendy A; Pizarro, Theresa T (2013) Regulatory cell populations in the intestinal mucosa. Curr Opin Gastroenterol 29:614-20
Pastorelli, Luca; De Salvo, Carlo; Vecchi, Maurizio et al. (2013) The role of IL-33 in gut mucosal inflammation. Mediators Inflamm 2013:608187

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