The Administrative Core provides strong centralized scientific and administrative leadership to the PPG, which facilitates synergistic interactions between the four projects and the other core and maintains the overall focus of the program project. Dr. Fabio Cominelli, Program Director, has primary responsibility for all aspects of the program. He will be assisted by the Executive Committee (project and core leaders), as well as the Internal and Extemal Advisory Boards. This core will oversee all annual budgets, monitor expenses and provide monthly statements of financial activities to the four projects and two cores. In addition, all program-related meetings will be scheduled through the core. These include the bi-weekly meeting of the Executive Committee to evaluate productivity, allocation of core usage, and program resources, discussions of future directions as well as presentation of research in progress, identification of problems and discussion of alternative approaches and solutions. The Adminstrative Core will also offer centralized biostatistical and manuscript support to all the projects. The enrichment program ofthe Administrative Core will arrange for the Annual Meeting of the Extemal Advisory Board as well as the Annual Intemational Scientific Workshop. In addition, generation of materials to be reviewed by the Advisory Boards will be handled through the Administrative Core. Finally, the Administrative Core will prepare, generate and assemble materials required for the annual progress reports and will insure that all additional NIH and institutional reporting requirements concerning PPG activities are fulfilled in a timely manner.
CD affects more than 500,000 individuals in the US and incurs significant costs to society. Understanding the precise mechanisms and immune defects that cause the disease will allow us to develop better therapies and begin to develop a cure for this devastating disease.
|Kumar, Anand; Davenport, Karen Walston; Vuyisich, Grace et al. (2018) Complete Genome Sequences of Historic Clostridioides difficile Food-Dwelling Ribotype 078 Strains in Canada Identical to That of the Historic Human Clinical Strain M120 in the United Kingdom. Microbiol Resour Announc 7:|
|Rathkey, Joseph K; Zhao, Junjie; Liu, Zhonghua et al. (2018) Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis. Sci Immunol 3:|
|Mehta, Kathan; Jaiswal, Palashkumar; Briggs, Farren et al. (2018) In-patient outcomes of Hematopoietic Stem Cell Transplantation in Patients with Immune Mediated Inflammatory Diseases: A Nationwide Study. Sci Rep 8:6825|
|Yang, Jie; Liu, Zhonghua; Wang, Chuanping et al. (2018) Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc Natl Acad Sci U S A 115:6792-6797|
|Liu, Zhonghua; Wang, Chuanping; Rathkey, Joseph K et al. (2018) Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition. Structure 26:778-784.e3|
|Perez, Jessica M; Chen, Yinghua; Xiao, Tsan S et al. (2018) Phosphorylation of the E3 ubiquitin protein ligase ITCH diminishes binding to its cognate E2 ubiquitin ligase. J Biol Chem 293:1100-1105|
|Rodriguez-Palacios, Alexander; Aladyshkina, Natalia; Ezeji, Jessica C et al. (2018) 'Cyclical Bias' in Microbiome Research Revealed by A Portable Germ-Free Housing System Using Nested Isolation. Sci Rep 8:3801|
|Chirieleison, Steven M; Rathkey, Joseph K; Abbott, Derek W (2018) Unique BIR domain sets determine inhibitor of apoptosis protein-driven cell death and NOD2 complex signal specificity. Sci Signal 11:|
|Goodman, Wendy A; Havran, Hannah L; Quereshy, Humzah A et al. (2018) Estrogen Receptor ? Loss-of-Function Protects Female Mice From DSS-Induced Experimental Colitis. Cell Mol Gastroenterol Hepatol 5:630-633.e1|
|Li, Zhaodong; Buttó, Ludovica F; Buela, Kristine-Anne et al. (2018) Death Receptor 3 Signaling Controls the Balance between Regulatory and Effector Lymphocytes in SAMP1/YitFc Mice with Crohn's Disease-Like Ileitis. Front Immunol 9:362|
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