The specific aims are to evaluate whether prenatal and early-life exposures to the endocrine disruptors, bisphenol A (BPA) and polycyclic aromatic hydrocarbons (PAH), during pregnancy and early-childhood are associated with obesity and metabolic syndrome among children during early adolescence. The research will be conducted within the ongoing longitudinal birth cohort of African American and Dominican children from inner-city communities in New York City being conducted by the Columbia Center for Children's Environmental Health. BPA and PAH exposures are widespread among cohort mothers and children. Both compounds have been linked to obesity and metabolic syndrome in experimental and preliminary human studies. The research is timely;childhood obesity is increasing rapidly within the United States, with rates highest among minority populations. By age 5 years, 43% of our cohort children exceed the 85% of weight for age. The epidemic is likely to have significant public health implications, particularly among minority populations, as obesity is linked to risk of type 2 diabetes and cardiovascular disease. We propose to follow the children in the cohort to age 8-10 years and will assess height, weight, and body composition at ages 5, 7 and 8-10 years and metabolic syndrome components at ages 8-10. Exposure dosimeters are PAH concentrations in maternal prenatal personal air samples and PAH and BPA metaboltites concentrations in urine samples collected and stored from the mother during pregnancy and from the child at ages 3,5, and 7 years. We hypothesize that prenatal exposure to PAH and BPA (1) will be associated with higher weight gain trajectories from age 5 to 8-10, and at age 8-10 years with BMI z-score, fat mass and metabolic syndrome components and (2) will alter the methylation status of key genes involved in adipogenesis and hunger control measured in umbilical cord while blood cells, which will mediate the association between postnatal exposures to the endocrine disruptors and childhood obesity outcomes. The research will provide important data on whether prenatal/early-life expsoures to endocrine disruptors predicts childhood obesity/metabolic syndrome and will test hypotheses regarding underlying epigenentic mechansisms.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES009600-15
Application #
8515206
Study Section
Special Emphasis Panel (ZES1-LKB-G)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
15
Fiscal Year
2013
Total Cost
$182,182
Indirect Cost
$81,319
Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Rauh, Virginia A; Margolis, Amy E (2016) Research Review: Environmental exposures, neurodevelopment, and child mental health - new paradigms for the study of brain and behavioral effects. J Child Psychol Psychiatry 57:775-93
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Miller, Rachel L; Yan, Zhonghai; Maher, Christina et al. (2016) Impact of prenatal polycyclic aromatic hydrocarbon exposure on behavior, cortical gene expression and DNA methylation of the Bdnf gene. Neuroepigenetics 5:11-18
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Lovinsky-Desir, Stephanie; Miller, Rachel L; Bautista, Joshua et al. (2016) Differences in Ambient Polycyclic Aromatic Hydrocarbon Concentrations between Streets and Alleys in New York City: Open Space vs. Semi-Closed Space. Int J Environ Res Public Health 13:
Perera, Frederica; Nolte, Emily L Roen; Wang, Ya et al. (2016) Bisphenol A exposure and symptoms of anxiety and depression among inner city children at 10-12 years of age. Environ Res 151:195-202
Widen, Elizabeth M; Whyatt, Robin M; Hoepner, Lori A et al. (2016) Gestational weight gain and obesity, adiposity and body size in African-American and Dominican children in the Bronx and Northern Manhattan. Matern Child Nutr 12:918-28
Peterson, Bradley S; Rauh, Virginia A; Bansal, Ravi et al. (2015) Effects of prenatal exposure to air pollutants (polycyclic aromatic hydrocarbons) on the development of brain white matter, cognition, and behavior in later childhood. JAMA Psychiatry 72:531-40
Just, Allan C; Miller, Rachel L; Perzanowski, Matthew S et al. (2015) Vinyl flooring in the home is associated with children's airborne butylbenzyl phthalate and urinary metabolite concentrations. J Expo Sci Environ Epidemiol 25:574-9
Choi, Hyunok; Melly, Steven; Spengler, John (2015) Intraurban and longitudinal variability of classical pollutants in Kraków, Poland, 2000-2010. Int J Environ Res Public Health 12:4967-91

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