For the past 10 years, the Center's Biorepository Core (formerly the Laboratory Service Core) has provided crucial infrastructure for collecting, handling, processing, analyzing, and banking valuable biological and environmental samples collected under Center projects. Additionally, the Core has developed and validated innovative high-throughput methods to study numerous biological endpoints. Through the development of standard operating procedures, customized databases, comprehensive data tracking procedures, and a strong Quality Management Plan, the Core has banked thousands of blood, urine, saliva, dust, teeth, breastmilk, and other samples that can be used to answer scientific questions for decades to come. Over the next 5 years, the primary goals of the Biorepository Core will be to continue to provide infrastructure and support to the Center's research. Core staff will perform key laboratory functions, collecting, processing, and storing new samples and optimally maintaining banked samples. They will oversee the development and implementation of protocols for new and existing specimens and will coordinate shipment of samples between the Field Office, Biorepository, and collaborating analytical laboratories. Core staff will continue to ensure compliance with quality assurance and quality control procedures related to all aspects of sample collection, processing, shipping, storage, and data management. In addition, they will conduct validation pilot studies for new biomarkers. The Center Biorepository has become a division of the newly created UC Berkeley, School of Public Health Biorepository. By pooling infrastructure and resources within the university, the Biorepository Core will expand its ability to provide state of the art laboratory support to the Center's research projects.
The specific aims of the Biorepository Core are: 1. To preserve existing biological and environmental samples collected by the Center, and to coordinate additional processing, distribution, and analysis of these samples for proposed research projects. 2. To collect, process, bank, and analyze new biological samples from CHAMACOS participants at 9 and 12 years, and to coordinate sample transfer to analytical laboratories for analysis. 3. To implement and ensure compliance with quality assurance and quality control procedures for all aspects of sample collection, handling, data management, and analysis. 4. To develop procedures, in accordance with our Resource Sharing Plan, to optimize information on available biological and environmental specimens generated by the Center and make these resources available to other researchers.

Public Health Relevance

This Core will maintain and expand a vast collection of biological and environmental samples for current research projects and future collaborations, with a focus on QA/QC. The Core will support development and validation of new biomarkers to assess prenatal and child exposures to DDT, Mn, and PBDEs and will also support studies examining the association of exposure to DNA methylation with puberty onset. The Core will be a model for studies seeking to bank biological and environmental specimens for health research.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Research Program Projects (P01)
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Special Emphasis Panel (ZES1-LKB-G)
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University of California Berkeley
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Huen, Karen; Yousefi, Paul; Bradman, Asa et al. (2014) Effects of age, sex, and persistent organic pollutants on DNA methylation in children. Environ Mol Mutagen 55:209-22
Mora, Ana M; van Wendel de Joode, Berna; Mergler, Donna et al. (2014) Blood and hair manganese concentrations in pregnant women from the infants' environmental health study (ISA) in Costa Rica. Environ Sci Technol 48:3467-76
Dannemiller, K C; Mendell, M J; Macher, J M et al. (2014) Next-generation DNA sequencing reveals that low fungal diversity in house dust is associated with childhood asthma development. Indoor Air 24:236-47
Gunier, R B; Jerrett, M; Smith, D R et al. (2014) Determinants of manganese levels in house dust samples from the CHAMACOS cohort. Sci Total Environ 497-498:360-8
Chopra, Vidita; Harley, Kim; Lahiff, Maureen et al. (2014) Association between phthalates and attention deficit disorder and learning disability in U.S. children, 6-15 years. Environ Res 128:64-9
Alkon, Abbey; Harley, Kim G; Neilands, Torsten B et al. (2014) Latino children's body mass index at 2-3.5 years predicts sympathetic nervous system activity at 5 years. Child Obes 10:214-24
Rosas, Lisa G; Trujillo, Celina; Camacho, Jose et al. (2014) Acceptability of health information technology aimed at environmental health education in a prenatal clinic. Patient Educ Couns 97:244-7
Warner, Marcella; Wesselink, Amelia; Harley, Kim G et al. (2014) Prenatal exposure to dichlorodiphenyltrichloroethane and obesity at 9 years of age in the CHAMACOS study cohort. Am J Epidemiol 179:1312-22
Alkon, Abbey; Boyce, W Thomas; Tran, Linh et al. (2014) Prenatal adversities and Latino children's autonomic nervous system reactivity trajectories from 6 months to 5 years of age. PLoS One 9:e86283
Eskenazi, B; Bradman, A; Finkton, D et al. (2013) A rapid questionnaire assessment of environmental exposures to pregnant women in the INTERGROWTH-21st Project. BJOG 120 Suppl 2:129-38, v

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