Abstract

The Toxicology Research Center at the University at Buffalo will serve as the core analytical toxicology facility for this program. The core facility will supply analytical toxicology and exposure assessment expertise. Samples supplied to the core facility will be analyzed for PCB congeners, selected pesticides (DDE, HCB, Mirex etc.), and the heavy metals lead and methylmercury. Sample matrices to be analyzed include serum (PCBs, pesticides & methylmercury). The core facility will also develop and standardized methods for analysis of hydroxylated PCB metabolites in serum and milk. In order to assess total exposure to compounds having dioxin-like luciferase reporter gene assay, developed in the Toxicology Center. The core facility will collaborate with all investigators in experimental design, data analysis and report and manuscript preparations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
1P01ES011263-01
Application #
6549200
Study Section
Special Emphasis Panel (ZES1)
Project Start
2001-09-30
Project End
2006-09-29
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
University of Illinois Urbana-Champaign
Department
Type
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820

  Publications

Strakovsky, Rita S; Wang, Huan; Engeseth, Nicki J et al. (2015) Developmental bisphenol A (BPA) exposure leads to sex-specific modification of hepatic gene expression and epigenome at birth that may exacerbate high-fat diet-induced hepatic steatosis. Toxicol Appl Pharmacol 284:101-12
Peck, Jennifer David; Sweeney, Anne M; Symanski, Elane et al. (2010) Intra- and inter-individual variability of urinary phthalate metabolite concentrations in Hmong women of reproductive age. J Expo Sci Environ Epidemiol 20:90-100
Schantz, Susan L; Gardiner, Joseph C; Aguiar, Andréa et al. (2010) Contaminant profiles in Southeast Asian immigrants consuming fish from polluted waters in northeastern Wisconsin. Environ Res 110:33-9
Sable, Helen J K; Eubig, Paul A; Powers, Brian E et al. (2009) Developmental exposure to PCBs and/or MeHg: effects on a differential reinforcement of low rates (DRL) operant task before and after amphetamine drug challenge. Neurotoxicol Teratol 31:149-58
Dreiem, Anne; Shan, Mangting; Okoniewski, Richard J et al. (2009) Methylmercury inhibits dopaminergic function in rat pup synaptosomes in an age-dependent manner. Neurotoxicol Teratol 31:312-7
Powers, Brian E; Poon, Emily; Sable, Helen J K et al. (2009) Developmental exposure to PCBs, MeHg, or both: long-term effects on auditory function. Environ Health Perspect 117:1101-7
Pessah, Isaac N; Seegal, Richard F; Lein, Pamela J et al. (2008) Immunologic and neurodevelopmental susceptibilities of autism. Neurotoxicology 29:532-45
Kornosky, Jennifer L; Peck, Jennifer D; Sweeney, Anne M et al. (2008) Reproductive characteristics of Southeast Asian immigrants before and after migration. J Immigr Minor Health 10:135-43
Lyng, Gregory D; Seegal, Richard F (2008) Polychlorinated biphenyl-induced oxidative stress in organotypic co-cultures: experimental dopamine depletion prevents reductions in GABA. Neurotoxicology 29:301-8
Lyng, Gregory D; Snyder-Keller, Abigail; Seegal, Richard F (2007) Dopaminergic development of prenatal ventral mesencephalon and striatum in organotypic co-cultures. Brain Res 1133:1-9

Showing the most recent 10 out of 24 publications