Abstract

The overall goal of the Animal Exposure and Assessment Core is to provide support to investigators studying? the impact of oxidant air pollutants on allergic airways disease in infant rhesus monkeys. The Core is housed in? the Exposure Facility at the California National Primate Research Center (CNPRC). The Exposure Facility at? the CNPRC has well-established facilities for assessing all aspects of exposure to oxidant gases with validated? exposure conditions, and has a complete pulmonary function testing unit. Specifically, Core B will:? 1. Provide accurate and carefully controlled exposures of animals or in vitro preparations to selected types? and concentrations of air pollutants.? 2. Develop methods of inhalation exposure and atmosphere characterization.? 3. Coordinate purchase, health services and care for experimental animals.? 4. Provide logistical and technical support in ensuring experimental regimens are implemented correctly.? 5. Collate all exposure and pulmonary function data and to provide this to the experimental units.? 6. Coordinate acquisition of tissues at necropsy, and maintain the archive of collections and log of sample? custody and storage.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES011617-05
Application #
7466359
Study Section
Special Emphasis Panel (ZES1)
Project Start
Project End
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
5
Fiscal Year
2007
Total Cost
$167,299
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Crowley, Candace M; Fontaine, Justin H; Gerriets, Joan E et al. (2017) Early life allergen and air pollutant exposures alter longitudinal blood immune profiles in infant rhesus monkeys. Toxicol Appl Pharmacol 328:60-69
Herring, Matt J; Avdalovic, Mark V; Lasley, Bill et al. (2016) Elderly Female Rhesus Macaques Preserve Lung Alveoli With Estrogen/Progesterone Therapy. Anat Rec (Hoboken) 299:973-8
Akhter, Hasina; Ballinger, Carol; Liu, Nianjun et al. (2015) Cyclic Ozone Exposure Induces Gender-Dependent Neuropathology and Memory Decline in an Animal Model of Alzheimer's Disease. Toxicol Sci 147:222-34
Clay, Candice C; Maniar-Hew, Kinjal; Gerriets, Joan E et al. (2014) Early life ozone exposure results in dysregulated innate immune function and altered microRNA expression in airway epithelium. PLoS One 9:e90401
Maniar-Hew, Kinjal; Clay, Candice C; Postlethwait, Edward M et al. (2013) Innate immune response to LPS in airway epithelium is dependent on chronological age and antecedent exposures. Am J Respir Cell Mol Biol 49:710-20
Schroeter, Jeffry D; Asgharian, Bahman; Price, Owen T et al. (2013) Computational fluid dynamics simulations of inhaled nano- and microparticle deposition in the rhesus monkey nasal passages. Inhal Toxicol 25:691-701
Adgent, Margaret A; Squadrito, Giuseppe L; Ballinger, Carol A et al. (2012) Desferrioxamine inhibits protein tyrosine nitration: mechanisms and implications. Free Radic Biol Med 53:951-61
Asgharian, Bahman; Price, Owen; McClellan, Gene et al. (2012) Development of a rhesus monkey lung geometry model and application to particle deposition in comparison to humans. Inhal Toxicol 24:869-99
Corley, Richard A; Kabilan, Senthil; Kuprat, Andrew P et al. (2012) Comparative computational modeling of airflows and vapor dosimetry in the respiratory tracts of rat, monkey, and human. Toxicol Sci 128:500-16
Neradilek, Moni B; Polissar, Nayak L; Einstein, Daniel R et al. (2012) Branch-based model for the diameters of the pulmonary airways: accounting for departures from self-consistency and registration errors. Anat Rec (Hoboken) 295:1027-44

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