The Administrative Core will provide overall support for all projects and cores in this proposed competing renewal, with equal allocation of resources across projects. The Administrative Core Director is the PI for this proposal and will coordinate the Program's overall scientific and administrative activities, set project goals and timelines, direct the Executive Committee, implement common policies and procedures, review the quality of data and productivity of the projects and cores, as well as coordinate input from both Internal and External Advisory Committees. The Core will coordinate interactions with NIEHS, subcontracts and collaborators. The Core will assist the protection of human subjects. It will supervise and monitor finances for the Program. Central to the continued success of this Program will be its ability to promote interproject/ core interactions. The Core will coordinate the monthly meetings of the Program's Executive Committee. An Internal Advisory Committee will review the Program's projects biannually. An External Advisory Committee will provide oversight annually, as it has previously. Research findings will be presented at weekly laboratory meetings, monthly research-in-progress meetings attended by all members of the Executive Committee, as well as at other forums, including biannual mini-retreats. A key function will be to coordinate and optimize the transfer of scientific knowledge into clinical and public health practice. This goal will be achieved by focusing on five objectives for the Administrative Core: 1) promote the conduct of high impact research;2) develop patents, specialized cell lines, models, and experimental models and tools and meet biannually with the University's technology transfer office liaison to facilitate licensing, patenting, and other forms of technology transfer;3) communicate findings to those who can use them to impact clinical practice;4) communicate findings of research to those who can effect changes in institutional behavior, workplace and environmental safety, and public policy;5) train students and fellows who will pursue careers in translational and clinical research, as we have in the past. Based on the Director's past experience in leading Administrative Cores, and based on our experience as a Program for the past five years, this Core is a key tool for creating synergy and perpetuating this group of investigators'success in generating results that improve our understanding of disease mechanism while also improving clinical and public health practice in the field of environmental and occupational health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES011810-10
Application #
8462259
Study Section
Special Emphasis Panel (ZES1-TN-J)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
10
Fiscal Year
2013
Total Cost
$73,091
Indirect Cost
$24,848
Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Mroz, Margaret M; Ferguson, John H; Faino, Anna V et al. (2018) Effect of inhaled corticosteroids on lung function in chronic beryllium disease. Respir Med 138S:S14-S19
Li, Li; Silveira, Lori J; Hamzeh, Nabeel et al. (2016) Beryllium-induced lung disease exhibits expression profiles similar to sarcoidosis. Eur Respir J 47:1797-808
Falta, M T; Tinega, A N; Mack, D G et al. (2016) Metal-specific CD4+ T-cell responses induced by beryllium exposure in HLA-DP2 transgenic mice. Mucosal Immunol 9:218-28
Tooker, Brian C; Ozawa, Katherine; Newman, Lee S (2016) CpG promoter methylation status is not a prognostic indicator of gene expression in beryllium challenge. J Immunotoxicol 13:417-27
Fontenot, Andrew P; Falta, Michael T; Kappler, John W et al. (2016) Beryllium-Induced Hypersensitivity: Genetic Susceptibility and Neoantigen Generation. J Immunol 196:22-7
McKee, A S; Mack, D G; Crawford, F et al. (2015) MyD88 dependence of beryllium-induced dendritic cell trafficking and CD4? T-cell priming. Mucosal Immunol 8:1237-47
Tooker, Brian C; Brindley, Stephen M; Chiarappa-Zucca, Marina L et al. (2015) Accelerator mass spectrometry detection of beryllium ions in the antigen processing and presentation pathway. J Immunotoxicol 12:181-7
Li, Li; Hamzeh, Nabeel; Gillespie, May et al. (2015) Beryllium increases the CD14(dim)CD16+ subset in the lung of chronic beryllium disease. PLoS One 10:e0117276
Clayton, Gina M; Wang, Yang; Crawford, Frances et al. (2014) Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity. Cell 158:132-42
Mack, Douglas G; Falta, Michael T; McKee, Amy S et al. (2014) Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease. Proc Natl Acad Sci U S A 111:8553-8

Showing the most recent 10 out of 68 publications