The proposed new Children's Environmental Health Center based at the University of California, Berkeley is designed to examine the effects of in utero and early life exposure to potentially carcinogenic chemicals present in homes (i.e., pesticides, tobacco-related and epigenetic factors and their interplay in the development of childhood leukemia. The proposed Center, referred to as Center for Interdisciplinary Research on Childhood Leukemia and the Environment (CIRCLE) includes three Research Projects and two Cores as follows: Project 1 (Childhood Leukemia International Consortium Studies) will identify the exposures to the most relevant time periods and childhood leukemia subtypes and identify important genetic polymorphisms that can modify the association between childhood leukemia and parental tobacco smoking or home pesticide exposure by pooling data from 19 studies worldwide;Project 2 (Exposure Assessment for Childhood Leukemia) y /ill assess carcinogen exposures, based upon analysis of house dust and blood specimens, with special interest in tobacco-related contaminants, PCBs, and PBDEs;Project 3 (Prenatal exposures, DNA Methylation, &Childhood Leukemia) will provide a clearer understanding of the association between parental smoking, pesticides, PCBs, PBDEs exposures and DNA methylation patterns in childhood leukemia, using neonatal bloods. The Research Translation and Community Outreach Core (RTCO Core) will disseminate findings from each Project to various audiences with common interest in the etiology of childhood leukemia. The main objectives of Core A are to provide 1) oversight, coordination, and integration of Center activities;2) scientific leadership;and 3) centralized data management support. Core A will establish and manage Internal and External Advisory Committees;appoint and collaborate with two Pediatric Health Specialists, and support the research career development of new, junior faculty-level investigators within the structure of the Center. Core A will coordinate Community Engagement through the RTCO Core, assisted by the pediatric Health Specialists.
The purpose of this Program is to assess the role played by potentially cancer-causing chemicals in the risk of childhood leukemia. We will work with an international consortium of epidemiologic studies, and use stateof- the-art methods to both measure these chemicals and establish epigenetic mechanisms by which they influence risk. Outreach efforts will disseminate results to the community and policymakers.
|de Smith, Adam J; Kaur, Maneet; Gonseth, Semira et al. (2017) Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute Lymphoblastic Leukemia. Cancer Res 77:1674-1683|
|Wang, Rong; Wiemels, Joseph L; Metayer, Catherine et al. (2017) Cesarean Section and Risk of Childhood Acute Lymphoblastic Leukemia in a Population-Based, Record-Linkage Study in California. Am J Epidemiol 185:96-105|
|Gunier, Robert B; Kang, Alice; Hammond, S Katharine et al. (2017) A task-based assessment of parental occupational exposure to pesticides and childhood acute lymphoblastic leukemia. Environ Res 156:57-62|
|Marcotte, Erin L; Thomopoulos, Thomas P; Infante-Rivard, Claire et al. (2016) Caesarean delivery and risk of childhood leukaemia: a pooled analysis from the Childhood Leukemia International Consortium (CLIC). Lancet Haematol 3:e176-85|
|de Smith, Adam J; Ojha, Juhi; Francis, Stephen S et al. (2016) Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia. Oncotarget 7:72733-72745|
|Metayer, Catherine; Petridou, Eleni; Aranguré, Juan Manuel Mejía et al. (2016) Parental Tobacco Smoking and Acute Myeloid Leukemia: The Childhood Leukemia International Consortium. Am J Epidemiol 184:261-73|
|Lee, Seung-Tae; Wiemels, Joseph L (2016) Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites. Nucleic Acids Res 44:1105-17|
|Morimoto, Libby M; McCauley, Kathryn; Ma, Xiaomei et al. (2016) Birth weight, fetal growth, and risk of pediatric rhabdomyosarcoma: an updated record linkage study in California. Ann Epidemiol 26:141-145|
|Metayer, Catherine; Dahl, Gary; Wiemels, Joe et al. (2016) Childhood Leukemia: A Preventable Disease. Pediatrics 138:S45-S55|
|Giddings, Brenda M; Whitehead, Todd P; Metayer, Catherine et al. (2016) Childhood leukemia incidence in California: High and rising in the Hispanic population. Cancer 122:2867-75|
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