The proposed new Children's Environmental Health Center based at the University of California, Berkeley is designed to examine the effects of in utero and early life exposure to potentially carcinogenic chemicals present in homes (i.e., pesticides, tobacco-related and epigenetic factors and their interplay in the development of childhood leukemia. The proposed Center, referred to as Center for Interdisciplinary Research on Childhood Leukemia and the Environment (CIRCLE) includes three Research Projects and two Cores as follows: Project 1 (Childhood Leukemia International Consortium Studies) will identify the exposures to the most relevant time periods and childhood leukemia subtypes and identify important genetic polymorphisms that can modify the association between childhood leukemia and parental tobacco smoking or home pesticide exposure by pooling data from 19 studies worldwide;Project 2 (Exposure Assessment for Childhood Leukemia) y /ill assess carcinogen exposures, based upon analysis of house dust and blood specimens, with special interest in tobacco-related contaminants, PCBs, and PBDEs;Project 3 (Prenatal exposures, DNA Methylation, &Childhood Leukemia) will provide a clearer understanding of the association between parental smoking, pesticides, PCBs, PBDEs exposures and DNA methylation patterns in childhood leukemia, using neonatal bloods. The Research Translation and Community Outreach Core (RTCO Core) will disseminate findings from each Project to various audiences with common interest in the etiology of childhood leukemia. The main objectives of Core A are to provide 1) oversight, coordination, and integration of Center activities;2) scientific leadership;and 3) centralized data management support. Core A will establish and manage Internal and External Advisory Committees;appoint and collaborate with two Pediatric Health Specialists, and support the research career development of new, junior faculty-level investigators within the structure of the Center. Core A will coordinate Community Engagement through the RTCO Core, assisted by the pediatric Health Specialists.

Public Health Relevance

The purpose of this Program is to assess the role played by potentially cancer-causing chemicals in the risk of childhood leukemia. We will work with an international consortium of epidemiologic studies, and use state of- the-art methods to both measure these chemicals and establish epigenetic mechanisms by which they influence risk. Outreach efforts will disseminate results to the community and policymakers.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Research Program Projects (P01)
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Special Emphasis Panel (ZES1-LKB-G (P1))
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Gray, Kimberly A
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University of California Berkeley
Public Health & Prev Medicine
Schools of Public Health
United States
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Zhang, L; Samad, A; Pombo-de-Oliveira, M S et al. (2015) Global characteristics of childhood acute promyelocytic leukemia. Blood Rev 29:101-25
Whitehead, Todd P; Metayer, Catherine; Ward, Mary H et al. (2014) Persistent organic pollutants in dust from older homes: learning from lead. Am J Public Health 104:1320-6
Xiao, Jianqiao; Lee, Seung-Tae; Xiao, Yuanyuan et al. (2014) PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia. Int J Cancer 135:1101-9
Brown, F Reber; Whitehead, Todd P; Park, June-Soo et al. (2014) Levels of non-polybrominated diphenyl ether brominated flame retardants in residential house dust samples and fire station dust samples in California. Environ Res 135:9-14
Bailey, Helen D; Fritschi, Lin; Infante-Rivard, Claire et al. (2014) Parental occupational pesticide exposure and the risk of childhood leukemia in the offspring: findings from the childhood leukemia international consortium. Int J Cancer 135:2157-72
Whitehead, Todd P; Brown, F Reber; Metayer, Catherine et al. (2014) Polychlorinated biphenyls in residential dust: sources of variability. Environ Sci Technol 48:157-64
Goodman, Michael; LaKind, Judy S; Fagliano, Jerald A et al. (2014) Cancer cluster investigations: review of the past and proposals for the future. Int J Environ Res Public Health 11:1479-99
de Smith, Adam J; Walsh, Kyle M; Ladner, Martha B et al. (2014) The role of KIR genes and their cognate HLA class I ligands in childhood acute lymphoblastic leukemia. Blood 123:2497-503
Metayer, Catherine; Milne, Elizabeth; Dockerty, John D et al. (2014) Maternal supplementation with folic acid and other vitamins and risk of leukemia in offspring: a Childhood Leukemia International Consortium study. Epidemiology 25:811-22
Francis, Stephen Starko; Selvin, Steve; Metayer, Catherine et al. (2014) Mode of delivery and risk of childhood leukemia. Cancer Epidemiol Biomarkers Prev 23:876-81

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