Although mouse allergen and pollutant exposures have been linked to asthma morbidity in poor minority populations, these factors do not account for most of the observed morbidity, so that additional environmental factors almost certainly contribute to asthma morbidity in this population. One intriguing environmental factor is diet since the population that is most affected by asthma morbidity and mortality-poor, predominantly African American populations- have a "Western style" diet that is low in anti-oxidant foods and high in saturated fats. The ASTHMA-DIET Center's overall hypothesis is that a low anti-oxidant, pro-inflammatory diet impairs the capacity to respond to oxidative stressors, thereby increasing susceptibility to pollutant and mouse allergen exposure. In Project 2, we hypothesize that altering anti-oxidant and inflammatory characteristics of the diet will (1) prevent oxidative stress (OS), (2) reduce basophil activation, (3) reduce airways inflammation, and (4) improve clinical outcomes in allergic asthma. We propose testing this hypothesis by conducting randomized, controlled trials of two dietary interventions: (1) broccoli sprouts (BS), which increase OS capacity in respiratory epithelium, and (2) the low-saturated fat, anti-inflammatory OmniHeart Diet (OHD). We will test the effects of BS and the OHD on OS, inflammation, basophil activation, and clinical outcomes in Baltimore City adults with mouse allergen-induced asthma. Findings from these studies will lend insight into the role of diet in increasing susceptibility to allergen exposure, potential mechanisms by which diet may influence allergic asthma, and the potential for treating allergic asthma with dietary interventions.

Public Health Relevance

Findings from the proposed studies will lend insight into impact of dietary factors on inner-city asthma. Specifically, the project will determine if dietary interventions can improve oxidative stress status, inflammation, and allergic asthma. The findings may support the use of dietary supplement or overhaul of diet in the treatment of allergic asthma.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES018176-04
Application #
8381502
Study Section
Special Emphasis Panel (ZES1-LKB-G)
Project Start
Project End
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
4
Fiscal Year
2012
Total Cost
$156,916
Indirect Cost
$48,082
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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Lu, Kim D; Phipatanakul, Wanda; Perzanowski, Matthew S et al. (2016) Atopy, but not obesity is associated with asthma severity among children with persistent asthma. J Asthma 53:1033-44
Sudini, Kuladeep; Diette, Gregory B; Breysse, Patrick N et al. (2016) A Randomized Controlled Trial of the Effect of Broccoli Sprouts on Antioxidant Gene Expression and Airway Inflammation in Asthmatics. J Allergy Clin Immunol Pract 4:932-40
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Brigham, Emily P; Kolahdooz, Fariba; Hansel, Nadia et al. (2015) Association between Western diet pattern and adult asthma: a focused review. Ann Allergy Asthma Immunol 114:273-80
Brigham, Emily P; McCormack, Meredith C; Takemoto, Clifford M et al. (2015) Iron status is associated with asthma and lung function in US women. PLoS One 10:e0117545
Keet, Corinne A; McCormack, Meredith C; Pollack, Craig E et al. (2015) Neighborhood poverty, urban residence, race/ethnicity, and asthma: Rethinking the inner-city asthma epidemic. J Allergy Clin Immunol 135:655-62
McCormack, Meredith C; Belli, Andrew J; Kaji, Deepak A et al. (2015) Obesity as a susceptibility factor to indoor particulate matter health effects in COPD. Eur Respir J 45:1248-57
Peng, Roger D; Butz, Arlene M; Hackstadt, Amber J et al. (2015) Estimating the health benefit of reducing indoor air pollution in a randomized environmental intervention. J R Stat Soc Ser A Stat Soc 178:425-443

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