Although mouse allergen and pollutant exposures have been linked to asthma morbidity in poor minority populations, these factors do not account for most of the observed morbidity, so that additional environmental factors almost certainly contribute to asthma morbidity in this population. One intriguing environmental factor is diet since the population that is most affected by asthma morbidity and mortalitypoor, predominantly African American populations- have a """"""""Western style"""""""" diet that is low in anti-oxidant foods and high in saturated fats. The ASTHMA-DIET Program's overall hypothesis is that a low antioxidant, pro-inflammatory diet impairs the capacity to respond to oxidative stressors, thereby increasing susceptibility to pollutant and mouse allergen exposure. The Data Management and Statistics Core (DMSC) will support the conduct of Projects 1, 2, and 3 of the ASTHMA-DIET Program. Specifically, the DMSC will develop recruitment and study subject tracking tools, data collection tools, and data management systems for the projects. The support services include data quality control/quality assurance, development of randomization schemes, and environmental and biologic specimen tracking. The DMSC will also conduct statistical analyses - from exploratory and interim analyses to final complex multivariate modeling under the direction of the senior biostatistician and Core Co-Leader. The DMSC also supports generation of abstracts and manuscripts. To facilitate interactions between the Environmental Assessment Core and the Projects, the DMSC manages a web-based data portal to facilitate quality control and transfer of environmental assay data to the DMSC. These activities to facilitate interactions will be expanded to include a bar-coding based sample tracking system that will be integrated with Project 3, which will support the conduct of the biomarker assays for Projects 1 and 2. The DMSC holds weekly Center-wide Data Management meetings to review current issues pertaining to any of its support activities. The DMSC serves a key support role, managing a very large amount of complex data which spans the spectrum from questionnaire data, clinical data, environmental exposure data, and biomarker data. The data management system serves to ensure integration of all Projects.

Public Health Relevance

The DMSC serves a key support role, managing a very large amount of complex data from multiple studies These data span the spectrum from questionnaire data, clinical data, environmental exposure data, and biomarker data. The DMSC serves to ensure integration of all Projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES018176-04
Application #
8381507
Study Section
Special Emphasis Panel (ZES1-LKB-G)
Project Start
Project End
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
4
Fiscal Year
2012
Total Cost
$192,047
Indirect Cost
$78,824
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Kolahdooz, Fariba; Butler, Jennie L; Christiansen, Karina et al. (2016) Food and Nutrient Intake in African American Children and Adolescents Aged 5 to 16 Years in Baltimore City. J Am Coll Nutr 35:205-16
Lu, Kim D; Phipatanakul, Wanda; Perzanowski, Matthew S et al. (2016) Atopy, but not obesity is associated with asthma severity among children with persistent asthma. J Asthma 53:1033-44
Sudini, Kuladeep; Diette, Gregory B; Breysse, Patrick N et al. (2016) A Randomized Controlled Trial of the Effect of Broccoli Sprouts on Antioxidant Gene Expression and Airway Inflammation in Asthmatics. J Allergy Clin Immunol Pract 4:932-40
Davis, Meghan F; Peng, Roger D; McCormack, Meredith C et al. (2015) Staphylococcus aureus colonization is associated with wheeze and asthma among US children and young adults. J Allergy Clin Immunol 135:811-3.e5
Sussan, Thomas E; Gajghate, Sachin; Chatterjee, Samit et al. (2015) Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function. Am J Physiol Lung Cell Mol Physiol 309:L27-36
Brigham, Emily P; Kolahdooz, Fariba; Hansel, Nadia et al. (2015) Association between Western diet pattern and adult asthma: a focused review. Ann Allergy Asthma Immunol 114:273-80
Brigham, Emily P; McCormack, Meredith C; Takemoto, Clifford M et al. (2015) Iron status is associated with asthma and lung function in US women. PLoS One 10:e0117545
Keet, Corinne A; McCormack, Meredith C; Pollack, Craig E et al. (2015) Neighborhood poverty, urban residence, race/ethnicity, and asthma: Rethinking the inner-city asthma epidemic. J Allergy Clin Immunol 135:655-62
McCormack, Meredith C; Belli, Andrew J; Kaji, Deepak A et al. (2015) Obesity as a susceptibility factor to indoor particulate matter health effects in COPD. Eur Respir J 45:1248-57
Peng, Roger D; Butz, Arlene M; Hackstadt, Amber J et al. (2015) Estimating the health benefit of reducing indoor air pollution in a randomized environmental intervention. J R Stat Soc Ser A Stat Soc 178:425-443

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