The specific aims of the Administrative Core are to: 1) Provide the administrative infrastructure for the Center, including the initial point of contact and information clearinghouse for all stakeholders, including collaborators, funding agencies, and the community. 2) Facilitate communication and collaboration between the three R0Is and the Analytical Facility Core. 3) Provide a platform for Center activities, including evaluation. 4) Manage all conference and workshop logistics. 5) Maintain the website and engage in community outreach by updating content with Center research and related activities. 6) Facilitate communication and collaboration across the currently funded Centers for Ocean and Human Health and applicable R0Is funded under the companion FOA RFA-ES-11-013. 7) Ensure all NIH reporting requirements are met.

Public Health Relevance

We envision that the Center will help define the public health risks of naturally produced HOCs, provide better informed fisheries management and aquaculture practices, assist with quantifying risks associated with seafood consumption, and help to design relevant multiple exposure studies with respect to HOC toxicity.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Research Program Projects (P01)
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Study Section
Special Emphasis Panel (ZES1-LKB-J (P1))
Program Officer
Tyson, Frederick L
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University of California San Diego
Schools of Earth Sciences/Natur
La Jolla
United States
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El Gamal, Abrahim; Agarwal, Vinayak; Diethelm, Stefan et al. (2016) Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair. Proc Natl Acad Sci U S A 113:3797-802
El Gamal, Abrahim; Agarwal, Vinayak; Rahman, Imran et al. (2016) Enzymatic Reductive Dehalogenation Controls the Biosynthesis of Marine Bacterial Pyrroles. J Am Chem Soc 138:13167-13170
Teufel, Robin; Agarwal, Vinayak; Moore, Bradley S (2016) Unusual flavoenzyme catalysis in marine bacteria. Curr Opin Chem Biol 31:31-9
Harvey, Elizabeth L; Deering, Robert W; Rowley, David C et al. (2016) A Bacterial Quorum-Sensing Precursor Induces Mortality in the Marine Coccolithophore, Emiliania huxleyi. Front Microbiol 7:59
Agarwal, Vinayak; Li, Jie; Rahman, Imran et al. (2015) Complexity of naturally produced polybrominated diphenyl ethers revealed via mass spectrometry. Environ Sci Technol 49:1339-46
Hong, Mee Young; Lumibao, Jan; Mistry, Prashila et al. (2015) Fish Oil Contaminated with Persistent Organic Pollutants Reduces Antioxidant Capacity and Induces Oxidative Stress without Affecting Its Capacity to Lower Lipid Concentrations and Systemic Inflammation in Rats. J Nutr 145:939-44
Agarwal, Vinayak; Diethelm, Stefan; Ray, Lauren et al. (2015) Chemoenzymatic Synthesis of Acyl Coenzyme A Substrates Enables in Situ Labeling of Small Molecules and Proteins. Org Lett 17:4452-5
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Millow, Christopher J; Mackintosh, Susan A; Lewison, Rebecca L et al. (2015) Identifying bioaccumulative halogenated organic compounds using a nontargeted analytical approach: seabirds as sentinels. PLoS One 10:e0127205
Shaul, Nellie J; Dodder, Nathan G; Aluwihare, Lihini I et al. (2015) Nontargeted biomonitoring of halogenated organic compounds in two ecotypes of bottlenose dolphins (Tursiops truncatus) from the Southern California Bight. Environ Sci Technol 49:1328-38

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