Specific Aims: Research Project 2 tests the hypotheses that polybrominated diphenyl ethers (PBDEs), perfluorinated chemicals (PFCs) and environmental organic acids (EOAs) accumulate differently in human fetuses than in pregnant women during mid-gestation, and that these chemical exposures negatively impact placental development and function, important outcomes that can adversely affect in utero growth and development. Accordingly, the goal is to compare 2nd trimester maternal serum, placenta and fetal liver levels of PBDEs, PFCs and select EOAs through traditional and novel biomonitoring approaches (Aim 1);and evaluate the relationship between these chemical exposures and disruptions of placental development by analyzing morphological and molecular markers of trophoblast differentiation and function (Aim 2).

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZES1-LKB-K (P0))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Francisco
San Francisco
United States
Zip Code
Vandenberg, Laura N; Gerona, Roy R; Kannan, Kurunthachalam et al. (2016) Erratum to: A round robin approach to the analysis of bisphenol a (BPA) in human blood samples. Environ Health 15:43
Gerona, Roy R; Pan, Janet; Zota, Ami R et al. (2016) Direct measurement of Bisphenol A (BPA), BPA glucuronide and BPA sulfate in a diverse and low-income population of pregnant women reveals high exposure, with potential implications for previous exposure estimates: a cross-sectional study. Environ Health 15:50
Johnson, Paula I; Koustas, Erica; Vesterinen, Hanna M et al. (2016) Application of the Navigation Guide systematic review methodology to the evidence for developmental and reproductive toxicity of triclosan. Environ Int 92-93:716-28
Wang, Aolin; Padula, Amy; Sirota, Marina et al. (2016) Environmental influences on reproductive health: the importance of chemical exposures. Fertil Steril 106:905-29
Vandenberg, Laura N; Gerona, Roy R; Kannan, Kurunthachalam et al. (2014) A round robin approach to the analysis of bisphenol A (BPA) in human blood samples. Environ Health 13:25
Koustas, Erica; Lam, Juleen; Sutton, Patrice et al. (2014) The Navigation Guide - evidence-based medicine meets environmental health: systematic review of nonhuman evidence for PFOA effects on fetal growth. Environ Health Perspect 122:1015-27
Woodruff, Tracey J; Sutton, Patrice (2014) The Navigation Guide systematic review methodology: a rigorous and transparent method for translating environmental health science into better health outcomes. Environ Health Perspect 122:1007-14
Vesterinen, Hanna M; Johnson, Paula I; Koustas, Erica et al. (2013) In Support of EHP's Proposal to Adopt the ARRIVE Guidelines. Environ Health Perspect 121:A325