Specific Aims: Research Project 2 tests the hypotheses that polybrominated diphenyl ethers (PBDEs), perfluorinated chemicals (PFCs) and environmental organic acids (EOAs) accumulate differently in human fetuses than in pregnant women during mid-gestation, and that these chemical exposures negatively impact placental development and function, important outcomes that can adversely affect in utero growth and development. Accordingly, the goal is to compare 2nd trimester maternal serum, placenta and fetal liver levels of PBDEs, PFCs and select EOAs through traditional and novel biomonitoring approaches (Aim 1);and evaluate the relationship between these chemical exposures and disruptions of placental development by analyzing morphological and molecular markers of trophoblast differentiation and function (Aim 2).

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
1P01ES022841-01
Application #
8533676
Study Section
Special Emphasis Panel (ZES1-LKB-K (P0))
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
1
Fiscal Year
2013
Total Cost
$151,847
Indirect Cost
$31,010
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
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Gerona, Roy R; Pan, Janet; Zota, Ami R et al. (2016) Direct measurement of Bisphenol A (BPA), BPA glucuronide and BPA sulfate in a diverse and low-income population of pregnant women reveals high exposure, with potential implications for previous exposure estimates: a cross-sectional study. Environ Health 15:50
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Vandenberg, Laura N; Gerona, Roy R; Kannan, Kurunthachalam et al. (2014) A round robin approach to the analysis of bisphenol A (BPA) in human blood samples. Environ Health 13:25
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