Specific Aims: This project will test the hypothesis that prenatal exposures to endocrine disrupting chemicals (EDCs) affect fetal growth?specifically birth weight and whether the infant is small for gestational age (SGA) at delivery?and that these adverse effects are magnified by chronic psychosocial stress. We will focus on two groups of EDCs?polybrominated diphenyl ethers (PBDEs) and perfluorinated chemicals (PFCs)?and measures of chronic psychosocial stress. First, we will evaluate the relationship between prenatal PBDE and PFC exposures and adverse birth weight outcomes (Aim 1). We will then integrate place based, perceptual, and biological measures of stress in the maternal-fetal unit to characterize chronic psychosocial stress during pregnancy and assess birth weight effects (Aim 2). Lastly, we will examine potential interactive effects of EDC and chronic psychosocial stress exposures on birth weight outcomes (Aim 3).

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES022841-02
Application #
8677896
Study Section
Special Emphasis Panel (ZES1-LKB-K)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
2
Fiscal Year
2014
Total Cost
$140,514
Indirect Cost
$25,363
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143