Specific Aims: This project will test the hypothesis that prenatal exposures to endocrine disrupting chemicals (EDCs) affect fetal growth?specifically birth weight and whether the infant is small for gestational age (SGA) at delivery?and that these adverse effects are magnified by chronic psychosocial stress. We will focus on two groups of EDCs?polybrominated diphenyl ethers (PBDEs) and perfluorinated chemicals (PFCs)?and measures of chronic psychosocial stress. First, we will evaluate the relationship between prenatal PBDE and PFC exposures and adverse birth weight outcomes (Aim 1). We will then integrate place based, perceptual, and biological measures of stress in the maternal-fetal unit to characterize chronic psychosocial stress during pregnancy and assess birth weight effects (Aim 2). Lastly, we will examine potential interactive effects of EDC and chronic psychosocial stress exposures on birth weight outcomes (Aim 3).

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES022841-02
Application #
8677896
Study Section
Special Emphasis Panel (ZES1-LKB-K)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
2
Fiscal Year
2014
Total Cost
$140,514
Indirect Cost
$25,363
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Robinson, Joshua F; Kapidzic, Mirhan; Gormley, Matthew et al. (2017) Transcriptional Dynamics of Cultured Human Villous Cytotrophoblasts. Endocrinology 158:1581-1594
Vandenberg, Laura N; Gerona, Roy R; Kannan, Kurunthachalam et al. (2016) Erratum to: A round robin approach to the analysis of bisphenol a (BPA) in human blood samples. Environ Health 15:43
Varshavsky, Julia R; Zota, Ami R; Woodruff, Tracey J (2016) A Novel Method for Calculating Potency-Weighted Cumulative Phthalates Exposure with Implications for Identifying Racial/Ethnic Disparities among U.S. Reproductive-Aged Women in NHANES 2001-2012. Environ Sci Technol 50:10616-10624
Johnson, Paula I; Koustas, Erica; Vesterinen, Hanna M et al. (2016) Application of the Navigation Guide systematic review methodology to the evidence for developmental and reproductive toxicity of triclosan. Environ Int 92-93:716-28
Lam, Juleen; Sutton, Patrice; Kalkbrenner, Amy et al. (2016) A Systematic Review and Meta-Analysis of Multiple Airborne Pollutants and Autism Spectrum Disorder. PLoS One 11:e0161851
Gerona, Roy R; Pan, Janet; Zota, Ami R et al. (2016) Direct measurement of Bisphenol A (BPA), BPA glucuronide and BPA sulfate in a diverse and low-income population of pregnant women reveals high exposure, with potential implications for previous exposure estimates: a cross-sectional study. Environ Health 15:50
Koustas, Erica; Lam, Juleen; Sutton, Patrice et al. (2014) The Navigation Guide - evidence-based medicine meets environmental health: systematic review of nonhuman evidence for PFOA effects on fetal growth. Environ Health Perspect 122:1015-27
Johnson, Paula I; Sutton, Patrice; Atchley, Dylan S et al. (2014) The Navigation Guide - evidence-based medicine meets environmental health: systematic review of human evidence for PFOA effects on fetal growth. Environ Health Perspect 122:1028-39
Vandenberg, Laura N; Gerona, Roy R; Kannan, Kurunthachalam et al. (2014) A round robin approach to the analysis of bisphenol A (BPA) in human blood samples. Environ Health 13:25
Woodruff, Tracey J; Sutton, Patrice (2014) The Navigation Guide systematic review methodology: a rigorous and transparent method for translating environmental health science into better health outcomes. Environ Health Perspect 122:1007-14

Showing the most recent 10 out of 11 publications