The Administrative &Biostatistics Core provides centralized scientific support and leadership that facilitates collaborations between the five Projects and the Mass Spectrometry Core. In addition, it maintains the overall focus of the Center. Dr. L. Jackson Roberts II, Principle Investigator, has primary responsibility for all aspects of the Center. The Administrative &Biostatistics Core will oversee all annual budgets, monitor expenses, and provide monthly statements of financial activity. Further, all Center-related meetings and travel will be organized and schieduled through this Core. These include a bimonthly steering committee meeting of all Project and Core Leaders to evaluate and discuss scientific progress, allocation of Core usage, and Center resources. Arrangements for the Oversight Committee and Scientific Advisory Committees meetings, planned for the second and fourth years of the Center period, as well as generation of materials to be reviewed, will be handled through the Administrative &Biostatistics Core. Additionally, this Core will organize and coordinate the annual retreat for Center participants and advisors. The Core will prepare and assemble materials required for the annual progress reports and will ensure all additional NIH and institutional reporting requirements concerning the Center's activities are fulfilled in a timely manner. The Administrative &Biostatistics Core will also house biostatistical support services for all members of the Center under the direction of biostatistician Dr. Yu Shyr.

Public Health Relevance

The Administrative &Biostatistics Core provides centralized scientific support and leadership that facilitates collaborations between the five Projects and the Mass Spectrometry Core. Biostatistics support is critical to the research studies proposed, to ensure that useful and usable data are generated and analyzed appropriately to meet study specific aims.

National Institute of Health (NIH)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Vanderbilt University Medical Center
United States
Zip Code
Simpson, Scott A; Zaccagni, Hayden; Bichell, David P et al. (2014) Acetaminophen attenuates lipid peroxidation in children undergoing cardiopulmonary bypass. Pediatr Crit Care Med 15:503-10
Shonesy, Brian C; Bluett, Rebecca J; Ramikie, Teniel S et al. (2014) Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation. Cell Rep 9:1644-53
Wu, Jing; Thabet, Salim R; Kirabo, Annet et al. (2014) Inflammation and mechanical stretch promote aortic stiffening in hypertension through activation of p38 mitogen-activated protein kinase. Circ Res 114:616-25
Xu, Shu; Hermanson, Daniel J; Banerjee, Surajit et al. (2014) Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network. J Biol Chem 289:6799-808
Neau, David B; Bender, Gunes; Boeglin, William E et al. (2014) Crystal structure of a lipoxygenase in complex with substrate: the arachidonic acid-binding site of 8R-lipoxygenase. J Biol Chem 289:31905-13
Shuck, Sarah C; Wauchope, Orrette R; Rose, Kristie L et al. (2014) Protein modification by adenine propenal. Chem Res Toxicol 27:1732-42
Hermanson, Daniel J; Gamble-George, Joyonna C; Marnett, Lawrence J et al. (2014) Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentation. Trends Pharmacol Sci 35:358-67
Dikalov, Sergey I; Nazarewicz, Rafal R; Bikineyeva, Alfiya et al. (2014) Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension. Antioxid Redox Signal 20:281-94
Kirabo, Annet; Fontana, Vanessa; de Faria, Ana P C et al. (2014) DC isoketal-modified proteins activate T cells and promote hypertension. J Clin Invest 124:4642-56
Trott, Daniel W; Thabet, Salim R; Kirabo, Annet et al. (2014) Oligoclonal CD8+ T cells play a critical role in the development of hypertension. Hypertension 64:1108-15

Showing the most recent 10 out of 31 publications