Abstract

The Core consists of two parts. The Scientific portion supports the activities of Harris and Sonner with analyses of inhaled anesthetic concentrations in perfusates. It supports the activities of Pearce and Sonner with analyses of receptors agonists and antagonists, namely CPP, etomidate, ketamine, midazolam, and propofol. The Administrative portion supports Eger's conduct of the biannual meetings, including activities preparatory to the meetings and moderation of the meetings. The activities extend to preparation of continuation reports to the NIH and oversight of the Program Project budget. The Administrative portion also provides support for the participation of the Advisory Board and ad hoc experts in the biannual meetings and for their advice to Eger beyond the times of the meetings.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
2P01GM047818-11
Application #
6807226
Study Section
Special Emphasis Panel (ZGM1-PS-2 (04))
Project Start
2004-08-01
Project End
2009-07-31
Budget Start
2004-08-01
Budget End
2005-07-31
Support Year
11
Fiscal Year
2004
Total Cost
$68,758
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Cai, Xiaoyun; Huang, Huizhen; Kuzirian, Marissa S et al. (2016) Generation of a KOR-Cre knockin mouse strain to study cells involved in kappa opioid signaling. Genesis 54:29-37
Zarnowska, E D; Rodgers, F C; Oh, I et al. (2015) Etomidate blocks LTP and impairs learning but does not enhance tonic inhibition in mice carrying the N265M point mutation in the beta3 subunit of the GABA(A) receptor. Neuropharmacology 93:171-178
Burkat, Paul M; Lor, Chong; Perouansky, Misha et al. (2014) Enhancement of ?5-containing ?-aminobutyric acid type A receptors by the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6) is abolished by the ?3(N265M) mutation. Anesth Analg 119:1277-84
Iyer, Sangeetha V; Chandra, Dave; Homanics, Gregg E (2014) GABAA-R ?4 subunits are required for the low dose locomotor stimulatory effect of alphaxalone, but not for several other behavioral responses to alphaxalone, etomidate or propofol. Neurochem Res 39:1048-56
Blednov, Yuri A; Benavidez, Jill M; Homanics, Gregg E et al. (2012) Behavioral characterization of knockin mice with mutations M287L and Q266I in the glycine receptor ?1 subunit. J Pharmacol Exp Ther 340:317-29
Borghese, Cecilia M; Blednov, Yuri A; Quan, Yu et al. (2012) Characterization of two mutations, M287L and Q266I, in the ?1 glycine receptor subunit that modify sensitivity to alcohols. J Pharmacol Exp Ther 340:304-16
Pearce, R A; Duscher, P; Van Dyke, K et al. (2012) Isoflurane impairs odour discrimination learning in rats: differential effects on short- and long-term memory. Br J Anaesth 108:630-7
Werner, D F; Swihart, A; Rau, V et al. (2011) Inhaled anesthetic responses of recombinant receptors and knockin mice harboring ?2(S270H/L277A) GABA(A) receptor subunits that are resistant to isoflurane. J Pharmacol Exp Ther 336:134-44
Chang, Ki-Young; Park, Young-Gyun; Park, Hye-Yeon et al. (2011) Lack of CaV3.1 channels causes severe motor coordination defects and an age-dependent cerebellar atrophy in a genetic model of essential tremor. Biochem Biophys Res Commun 410:19-23
Harris, R A; Osterndorff-Kahanek, E; Ponomarev, I et al. (2011) Testing the silence of mutations: Transcriptomic and behavioral studies of GABA(A) receptor ýý1 and ýý2 subunit knock-in mice. Neurosci Lett 488:31-5

Showing the most recent 10 out of 167 publications