The Administrative Core will perform all of the business functions requires to ensure the successful administrative oversight of the program. The centralization of supply and equipment purchasing, payroll processing, accounting and grant budget management is designed to provide administrative services in the most cost effective manner possible.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
5P01GM067166-09
Application #
8379475
Study Section
Special Emphasis Panel (ZRG1-CB-L)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
9
Fiscal Year
2012
Total Cost
$60,961
Indirect Cost
$23,789
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Jayakanthan, Samuel; Braiterman, Lelita T; Hasan, Nesrin M et al. (2017) Human copper transporter ATP7B (Wilson disease protein) forms stable dimers in vitro and in cells. J Biol Chem 292:18760-18774
Hamilton, James P; Koganti, Lahari; Muchenditsi, Abigael et al. (2016) Activation of liver X receptor/retinoid X receptor pathway ameliorates liver disease in Atp7B(-/-) (Wilson disease) mice. Hepatology 63:1828-41
Gupta, Arnab; Schell, Michael J; Bhattacharjee, Ashima et al. (2016) Myosin Vb mediates Cu+ export in polarized hepatocytes. J Cell Sci 129:1179-89
Krishnamoorthy, Lakshmi; Cotruvo Jr, Joseph A; Chan, Jefferson et al. (2016) Copper regulates cyclic-AMP-dependent lipolysis. Nat Chem Biol 12:586-92
Kline, Chelsey D; Gambill, Benjamin F; Mayfield, Mary et al. (2016) pH-regulated metal-ligand switching in the HM loop of ATP7A: a new paradigm for metal transfer chemistry. Metallomics 8:729-33
Clifford, Rebecca J; Maryon, Edward B; Kaplan, Jack H (2016) Dynamic internalization and recycling of a metal ion transporter: Cu homeostasis and CTR1, the human Cu? uptake system. J Cell Sci 129:1711-21
Dmitriev, Oleg Y; Lutsenko, Svetlana; Muyldermans, Serge (2016) Nanobodies as Probes for Protein Dynamics in Vitro and in Cells. J Biol Chem 291:3767-75
Braiterman, Lelita T; Gupta, Arnab; Chaerkady, Raghothama et al. (2015) Communication between the N and C termini is required for copper-stimulated Ser/Thr phosphorylation of Cu(I)-ATPase (ATP7B). J Biol Chem 290:8803-19
Braiterman, Lelita T; Murthy, Amrutha; Jayakanthan, Samuel et al. (2014) Distinct phenotype of a Wilson disease mutation reveals a novel trafficking determinant in the copper transporter ATP7B. Proc Natl Acad Sci U S A 111:E1364-73
Malinouski, Mikalai; Hasan, Nesrin M; Zhang, Yan et al. (2014) Genome-wide RNAi ionomics screen reveals new genes and regulation of human trace element metabolism. Nat Commun 5:3301

Showing the most recent 10 out of 67 publications