The purpose of the 'Administrative Core'is as follows: (1) provide overall scientific and administrative management of the Program Project;(2) schedule, organize, and run the yearly meeting of the Program Project;(3) schedule travel for PIs/postdocs/students to go from one of the two performance sites to the other in order to conduct research;(4) organize the functions of the External Advisory Committee;and (5) develop, organize, and oversee the web site of the Program Project.
Our studies are aimed at determining the elements of protein structure that create specific dynamics important for catalytic mechanism. We will understand design features that either up or down regulate enzymatic activity. The goal of this research is to lay a foundation for the development and rational design of 'allosteric'effectors or active site inhibitors based on dynamics.
|Zoi, Ioanna; Antoniou, Dimitri; Schwartz, Steven D (2017) Incorporating Fast Protein Dynamics into Enzyme Design: A Proposed Mutant Aromatic Amine Dehydrogenase. J Phys Chem B 121:7290-7298|
|Deng, Hua; Vedad, Jayson; Desamero, Ruel Z B et al. (2017) Difference FTIR Studies of Substrate Distribution in Triosephosphate Isomerase. J Phys Chem B 121:10036-10045|
|Khrapunov, Sergei; Chang, Eric; Callender, Robert H (2017) Thermodynamic and Structural Adaptation Differences between the Mesophilic and Psychrophilic Lactate Dehydrogenases. Biochemistry 56:3587-3595|
|Eismin, Ryan J; Munusamy, Elango; Kegel, Laurel L et al. (2017) Evolution of Aggregate Structure in Solutions of Anionic Monorhamnolipids: Experimental and Computational Results. Langmuir 33:7412-7424|
|Peng, Huo-Lei; Callender, Robert (2017) Mechanistic Analysis of Fluorescence Quenching of Reduced Nicotinamide Adenine Dinucleotide by Oxamate in Lactate Dehydrogenase Ternary Complexes. Photochem Photobiol 93:1193-1203|
|Davis, Caitlin M; Reddish, Michael J; Dyer, R Brian (2017) Dual time-resolved temperature-jump fluorescence and infrared spectroscopy for the study of fast protein dynamics. Spectrochim Acta A Mol Biomol Spectrosc 178:185-191|
|Reddish, Michael J; Callender, Robert; Dyer, R Brian (2017) Resolution of Submillisecond Kinetics of Multiple Reaction Pathways for Lactate Dehydrogenase. Biophys J 112:1852-1862|
|Zoi, Ioanna; Antoniou, Dimitri; Schwartz, Steven D (2017) Electric Fields and Fast Protein Dynamics in Enzymes. J Phys Chem Lett 8:6165-6170|
|Munusamy, Elango; Luft, Charles M; Pemberton, Jeanne E et al. (2017) Structural Properties of Nonionic Monorhamnolipid Aggregates in Water Studied by Classical Molecular Dynamics Simulations. J Phys Chem B 121:5781-5793|
|Brás, Natércia F; Fernandes, Pedro A; Ramos, Maria J et al. (2017) Mechanistic Insights on Human Phosphoglucomutase Revealed by Transition Path Sampling and Molecular Dynamics Calculations. Chemistry :|
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