The Analytical Resource Core will provide the researchers affiliated with the Program Project access to high performance analytical instrumentation, mass spectrometry (MS), and nuclear magnetic resonance spectroscopy (NMR), through training, experimental design and routine sample analysis. Coupled to these Instruments are nanocapillary chromatographs that allow separation and analysis of microscale experiments and culture extracts. The ability to analyze small amounts of material is crucial in the effort to employ MS and NMR In medium- and high-throughput screening campaigns for novel phosphonates. The Analytical Resource Core will also develop new methods and analyses that will accelerate the discovery and reengineering portions of the Research Projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
5P01GM077596-07
Application #
8457040
Study Section
Special Emphasis Panel (ZRG1-BCMB-U)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
7
Fiscal Year
2013
Total Cost
$202,666
Indirect Cost
$74,801
Name
University of Illinois Urbana-Champaign
Department
Type
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Zhao, Huimin; Medema, Marnix H (2016) Standardization for natural product synthetic biology. Nat Prod Rep 33:920-4
Chekan, Jonathan R; Cogan, Dillon P; Nair, Satish K (2016) Molecular Basis for Resistance Against Phosphonate Antibiotics and Herbicides. Medchemcomm 7:28-36
Zhang, Mingzi M; Wang, Yajie; Ang, Ee Lui et al. (2016) Engineering microbial hosts for production of bacterial natural products. Nat Prod Rep 33:963-87
Goering, Anthony W; McClure, Ryan A; Doroghazi, James R et al. (2016) Metabologenomics: Correlation of Microbial Gene Clusters with Metabolites Drives Discovery of a Nonribosomal Peptide with an Unusual Amino Acid Monomer. ACS Cent Sci 2:99-108
Ulrich, Emily C; van der Donk, Wilfred A (2016) Cameo appearances of aminoacyl-tRNA in natural product biosynthesis. Curr Opin Chem Biol 35:29-36
Freestone, Todd S; Zhao, Huimin (2016) Combinatorial pathway engineering for optimized production of the anti-malarial FR900098. Biotechnol Bioeng 113:384-92
Wendt, Kristen E; Ungerer, Justin; Cobb, Ryan E et al. (2016) CRISPR/Cas9 mediated targeted mutagenesis of the fast growing cyanobacterium Synechococcus elongatus UTEX 2973. Microb Cell Fact 15:115
Luo, Yunzi; Enghiad, Behnam; Zhao, Huimin (2016) New tools for reconstruction and heterologous expression of natural product biosynthetic gene clusters. Nat Prod Rep 33:174-82
Peck, Spencer C; van der Donk, Wilfred A (2016) Go it alone: four-electron oxidations by mononuclear non-heme iron enzymes. J Biol Inorg Chem :
Blodgett, Joshua Av; Zhang, Jun Kai; Yu, Xiaomin et al. (2016) Conserved biosynthetic pathways for phosalacine, bialaphos and newly discovered phosphonic acid natural products. J Antibiot (Tokyo) 69:15-25

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