Phosphonic acids are a potent, yet underexploited, group of compounds with great promise in the treatment of human disease. Numerous structurally distinct phosphonates are produced in nature and many have useful bioactive properties. Importantly, the biological targets of phosphonic acids vary substantially, allowing them to be used for treating a variety of health conditions. The potent bioactivity of phosphonates also allows their use as fungicides, herbicides and pesticides. In our Initial funding period we showed that phosphonate biosynthesis is surprisingly common in nature and that a wealth of uncharacterized natural products await characterization. In this sub-project we propose a series of molecular, genetic and biochemical experiments aimed at exploiting and expanding these discoveries.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
5P01GM077596-08
Application #
8634111
Study Section
Special Emphasis Panel (ZRG1-BCMB-U)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
8
Fiscal Year
2014
Total Cost
$422,754
Indirect Cost
$146,846
Name
University of Illinois Urbana-Champaign
Department
Type
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
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