Abstract

Context of this Project in the Sanders Lab The preliminary phase of this project is funded by the National Institute of Aging (NIA) under the R21 """"""""Exploratory/Developmental Research"""""""" program (PA-03-107). After administrative cuts to the original project budget, this R21 was funded for two years at <$120,000 direct per year over two years: 5/01/06-4/30/08. The R21 grant is non-renewable and is not eligible for conversion to an RO1 via competitive renewal. Therefore, this PPG proposal represents an effort to secure support in the form of a new grant to continue this work. There is one month of overlap between the proposed start date of this PPG (04/01/2008) and the end of the R21 that will need to be addressed at the administrative level if this PPG is funded. Data generated with the support of the R21 is presented here in the form of """"""""Preliminary Data"""""""".

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
5P01GM080513-05
Application #
8378852
Study Section
Special Emphasis Panel (ZRG1-BCMB-P)
Project Start
Project End
2014-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
5
Fiscal Year
2012
Total Cost
$304,406
Indirect Cost
$105,997

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Stein, Richard A; Beth, Albert H; Hustedt, Eric J (2015) A Straightforward Approach to the Analysis of Double Electron-Electron Resonance Data. Methods Enzymol 563:531-67
Edwards, Sarah J; Moth, Christopher W; Kim, Sunghoon et al. (2014) Automated structure refinement for a protein heterodimer complex using limited EPR spectroscopic data and a rigid-body docking algorithm: a three-dimensional model for an ankyrin-CDB3 complex. J Phys Chem B 118:4717-26
Smith, Jarrod A; Edwards, Sarah J; Moth, Christopher W et al. (2013) TagDock: an efficient rigid body docking algorithm for oligomeric protein complex model construction and experiment planning. Biochemistry 52:5577-84
Pester, Oxana; Barrett, Paul J; Hornburg, Daniel et al. (2013) The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of ?-secretase. J Am Chem Soc 135:1317-29
Song, Yuanli; Hustedt, Eric J; Brandon, Suzanne et al. (2013) Competition between homodimerization and cholesterol binding to the C99 domain of the amyloid precursor protein. Biochemistry 52:5051-64
Barrett, Paul J; Chen, Jiang; Cho, Min-Kyu et al. (2013) The quiet renaissance of protein nuclear magnetic resonance. Biochemistry 52:1303-20
Zhuang, Tiandi; Chen, Qiuyan; Cho, Min-Kyu et al. (2013) Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsin. Proc Natl Acad Sci U S A 110:942-7
Mittendorf, Kathleen F; Deatherage, Catherine L; Ohi, Melanie D et al. (2012) Tailoring of membrane proteins by alternative splicing of pre-mRNA. Biochemistry 51:5541-56
Deatherage, Catherine L; Hadziselimovic, Arina; Sanders, Charles R (2012) Purification and characterization of the human ?-secretase activating protein. Biochemistry 51:5153-9
Ghimire, Harishchandra; Hustedt, Eric J; Sahu, Indra D et al. (2012) Distance measurements on a dual-labeled TOAC AChR M2? peptide in mechanically aligned DMPC bilayers via dipolar broadening CW-EPR spectroscopy. J Phys Chem B 116:3866-73

Showing the most recent 10 out of 22 publications