The Administrative Core will provide centralized grant administration, oversight, and coordination of all fiscal and scientiflc components of the Program of Projects. This Includes clerical support and management of budgets. In addition, the Administrative Core will coordinate meetings with the External and Internal Scientific Advisory Boards. Dr. Jennifer Nyborg (Project 1) will serve as the Program Director for the POI and, as such, will also serve as Director of the Administrative Core. She will be responsible for oversight of the research projects, collaborations and communication between participants, and as the liaison with the Advisory Board members. She will also monitor the financial status of the each Project and Core, and work closely with the Program Leaders and PEP and Biophysics Core Directors. Through these structured mechanisms, the Administrative Core Insures high quality, team-oriented, productive Investigations. The Administrative Core will also oversee the development and maintenance of a Chromatin Intranet Website. This resource will allow timely dissemination of new Information, promote collaboration among team members, and provide a central location for Information resources. In summary, the goals of the Administrative Core are to: 1. Provide fiscal management and oversight of spending. 2. Encourage and facilitate communication and collaboration between the Program participants. 3. Provide administrative and clerical services for meeting planning and organization. 4. Implement the Chromatin Intranet Website for all Program participants.

Public Health Relevance

The Administrative Core is designed to provide investigators with mechanisms of scientific and administrative communication, to promote collaboration among team members, and facilitate tiie goals of the POI. Each of these activities is pivotal to maintaining tiie highly integrated stmcture of the Program of Projects and to maintaining optimal productivity and momentum towards the scientific goals.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-GGG-E)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Colorado State University-Fort Collins
Fort Collins
United States
Zip Code
Groocock, Lynda M; Nie, Minghua; Prudden, John et al. (2014) RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response. EMBO Rep 15:601-8
Muthurajan, Uma M; Hepler, Maggie R D; Hieb, Aaron R et al. (2014) Automodification switches PARP-1 function from chromatin architectural protein to histone chaperone. Proc Natl Acad Sci U S A 111:12752-7
Chodaparambil, Jayanth V; Pate, Kira T; Hepler, Margretta R D et al. (2014) Molecular functions of the TLE tetramerization domain in Wnt target gene repression. EMBO J 33:719-31
Kalashnikova, Anna A; Porter-Goff, Mary E; Muthurajan, Uma M et al. (2013) The role of the nucleosome acidic patch in modulating higher order chromatin structure. J R Soc Interface 10:20121022
Sheinin, Maxim Y; Li, Ming; Soltani, Mohammad et al. (2013) Torque modulates nucleosome stability and facilitates H2A/H2B dimer loss. Nat Commun 4:2579
Rogge, Ryan A; Kalashnikova, Anna A; Muthurajan, Uma M et al. (2013) Assembly of nucleosomal arrays from recombinant core histones and nucleosome positioning DNA. J Vis Exp :
Hsieh, Fu-Kai; Kulaeva, Olga I; Patel, Smita S et al. (2013) Histone chaperone FACT action during transcription through chromatin by RNA polymerase II. Proc Natl Acad Sci U S A 110:7654-9
Kalashnikova, Anna A; Winkler, Duane D; McBryant, Steven J et al. (2013) Linker histone H1.0 interacts with an extensive network of proteins found in the nucleolus. Nucleic Acids Res 41:4026-35
D'Arcy, Sheena; Martin, Kyle W; Panchenko, Tanya et al. (2013) Chaperone Nap1 shields histone surfaces used in a nucleosome and can put H2A-H2B in an unconventional tetrameric form. Mol Cell 51:662-77
Elsasser, Simon J; D'Arcy, Sheena (2012) Towards a mechanism for histone chaperones. Biochim Biophys Acta 1819:211-21

Showing the most recent 10 out of 17 publications