The Administrative Core will provide centralized grant administration, oversight, and coordination of all fiscal and scientiflc components of the Program of Projects. This Includes clerical support and management of budgets. In addition, the Administrative Core will coordinate meetings with the External and Internal Scientific Advisory Boards. Dr. Jennifer Nyborg (Project 1) will serve as the Program Director for the POI and, as such, will also serve as Director of the Administrative Core. She will be responsible for oversight of the research projects, collaborations and communication between participants, and as the liaison with the Advisory Board members. She will also monitor the financial status of the each Project and Core, and work closely with the Program Leaders and PEP and Biophysics Core Directors. Through these structured mechanisms, the Administrative Core Insures high quality, team-oriented, productive Investigations. The Administrative Core will also oversee the development and maintenance of a Chromatin Intranet Website. This resource will allow timely dissemination of new Information, promote collaboration among team members, and provide a central location for Information resources. In summary, the goals of the Administrative Core are to: 1. Provide fiscal management and oversight of spending. 2. Encourage and facilitate communication and collaboration between the Program participants. 3. Provide administrative and clerical services for meeting planning and organization. 4. Implement the Chromatin Intranet Website for all Program participants.

Public Health Relevance

The Administrative Core is designed to provide investigators with mechanisms of scientific and administrative communication, to promote collaboration among team members, and facilitate tiie goals of the POI. Each of these activities is pivotal to maintaining tiie highly integrated stmcture of the Program of Projects and to maintaining optimal productivity and momentum towards the scientific goals.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
5P01GM088409-04
Application #
8464753
Study Section
Special Emphasis Panel (ZRG1-GGG-E)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
4
Fiscal Year
2013
Total Cost
$410,675
Indirect Cost
$131,256
Name
Colorado State University-Fort Collins
Department
Type
DUNS #
785979618
City
Fort Collins
State
CO
Country
United States
Zip Code
80523
Chen, Xu; D'Arcy, Sheena; Radebaugh, Catherine A et al. (2016) Histone Chaperone Nap1 Is a Major Regulator of Histone H2A-H2B Dynamics at the Inducible GAL Locus. Mol Cell Biol 36:1287-96
White, Alison E; Hieb, Aaron R; Luger, Karolin (2016) A quantitative investigation of linker histone interactions with nucleosomes and chromatin. Sci Rep 6:19122
Chatterjee, Nilanjana; North, Justin A; Dechassa, Mekonnen Lemma et al. (2015) Histone Acetylation near the Nucleosome Dyad Axis Enhances Nucleosome Disassembly by RSC and SWI/SNF. Mol Cell Biol 35:4083-92
Brehove, Matthew; Wang, Tao; North, Justin et al. (2015) Histone core phosphorylation regulates DNA accessibility. J Biol Chem 290:22612-21
Kuo, Yin-Ming; Henry, Ryan A; Huang, Liangqun et al. (2015) Utilizing targeted mass spectrometry to demonstrate Asf1-dependent increases in residue specificity for Rtt109-Vps75 mediated histone acetylation. PLoS One 10:e0118516
Mattiroli, Francesca; D'Arcy, Sheena; Luger, Karolin (2015) The right place at the right time: chaperoning core histone variants. EMBO Rep 16:1454-66
Groocock, Lynda M; Nie, Minghua; Prudden, John et al. (2014) RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response. EMBO Rep 15:601-8
Muthurajan, Uma M; Hepler, Maggie R D; Hieb, Aaron R et al. (2014) Automodification switches PARP-1 function from chromatin architectural protein to histone chaperone. Proc Natl Acad Sci U S A 111:12752-7
Blakeslee, Weston W; Wysoczynski, Christina L; Fritz, Kristofer S et al. (2014) Class I HDAC inhibition stimulates cardiac protein SUMOylation through a post-translational mechanism. Cell Signal 26:2912-20
Chodaparambil, Jayanth V; Pate, Kira T; Hepler, Margretta R D et al. (2014) Molecular functions of the TLE tetramerization domain in Wnt target gene repression. EMBO J 33:719-31

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