Admin Core Abstract: The Administration Core will be directed by Dr. Harris and assisted by several University of Minnesota staff. The Administrafion Core will service the Program Project entified "Crifical Interactions of AP0BEC3s: Molecular Approaches to Novel HIV Therapies" by accomplishing the following specific aims: (i) work with an Advisory Board to evaluate progress and shape long-term research strategies, (ii) provide strong leadership and advice to program collaborators on research plans and logisfics, (iii) establish and maintain plasmid, oligonucleotide, protein, and inhibitor databases with an online request portal, (iv) facilitate bi-weekly program video teleconferences and an annual program retreat (coupled to an Advisory Board meeting), and (v) provide day-to-day administrafive support for travel arrangements, publications, web site updates, post-award reports, material transfer agreements, inter-lab reagent distributions, and any other program-relevant administrative tasks.
The interactions of the cellular APOBECS proteins and HIV Vif can dictate the fate of a viral infection. Our program scientists aim to provide the most comprehensive information to date on these life-or-death interactions, and strong leadership and efficient administration will be provided to help meet their scientific objectives.
|Shaban, Nadine M; Shi, Ke; Li, Ming et al. (2016) 1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal Structure. J Mol Biol 428:2307-16|
|Prabhu, Ponnandy; Shandilya, Shivender M D; Britan-Rosich, Elena et al. (2016) Inhibition of APOBEC3G activity impedes double-stranded DNA repair. FEBS J 283:112-29|
|Shlyakhtenko, Luda S; Dutta, Samrat; Li, Ming et al. (2016) Single-Molecule Force Spectroscopy Studies of APOBEC3A-Single-Stranded DNA Complexes. Biochemistry 55:3102-6|
|Sharma, Ashwani; Haque, Farzin; Pi, Fengmei et al. (2016) Controllable self-assembly of RNA dendrimers. Nanomedicine 12:835-44|
|Li, Hui; Zhang, Kaiming; Pi, Fengmei et al. (2016) Controllable Self-Assembly of RNA Tetrahedrons with Precise Shape and Size for Cancer Targeting. Adv Mater 28:7501-7|
|Lyubchenko, Yuri L; Shlyakhtenko, Luda S (2016) Imaging of DNA and Protein-DNA Complexes with Atomic Force Microscopy. Crit Rev Eukaryot Gene Expr 26:63-96|
|Li, Jinhui; Barylko, Barbara; Eichorst, John P et al. (2016) Association of Endophilin B1 with Cytoplasmic Vesicles. Biophys J 111:565-76|
|Khisamutdinov, Emil F; Jasinski, Daniel L; Li, Hui et al. (2016) Fabrication of RNA 3D Nanoprisms for Loading and Protection of Small RNAs and Model Drugs. Adv Mater 28:10079-10087|
|Kouno, Takahide; Luengas, Elizabeth M; Shigematsu, Megumi et al. (2015) Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G. Nat Struct Mol Biol 22:485-91|
|Shlyakhtenko, Luda S; Dutta, Samrat; Banga, Jaspreet et al. (2015) APOBEC3G Interacts with ssDNA by Two Modes: AFM Studies. Sci Rep 5:15648|
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