Core Structure The core will be overseen by Dr. Snyder and be managed by an Execufive Committee comprised of Drs. Snyder, Wu, Weissman, Wysocka, and Koller. To avoid conflict of interest and to have a broader representafion from the rest of the University, we will also have Dr. Irving Weissman (Director, Stanford Stem Cell Institute), Dr. Michael Longaker (co-Director, Stanford Stem Cell Institute), and Dr. Robert Robbins (Director, Stanford Cardiovascular Institute) as external panel members (see support letters). This core will meet biweekly physically (for the Stanford Pis) and by teleconference (for Weissman) and review scientific progress and discuss direcfions. The Execufive Committee will also review pilot project proposals. It is expected that all decisions will be met by consensus, but in the unlikely event that this is not possible, Dr. Snyder is responsible for final decisions. The Executive Committee will also interface with other funded members of the consortium which will allow us to coordinate acfivifies with other groups. If this format is not followed in this inifiative, then an external advisory board comprised of prominent members in the iPSC and genomics communifies will be formed and meet annually with our group. Scientific coordinafion will be mediated by Shin Lin, who is experienced with many of the techniques proposed and knows most of the Pis. He will be responsible for the day-to-day management of the enfire operafion. He will also be heavily engaged in Project 3. Communicafion between participants will be facilitated by Ms. Chrisfina Pack, who will assist Dr. Snyder and also be responsible for interface with other members of the epigenefics consortium.

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Patterson, Benjamin; Tanaka, Yoshiaki; Park, In-Hyun (2017) New Advances in Human X chromosome status from a Developmental and Stem Cell Biology. Tissue Eng Regen Med 14:643-652
Zhao, Ming-Tao; Shao, Ning-Yi; Hu, Shijun et al. (2017) Cell Type-Specific Chromatin Signatures Underline Regulatory DNA Elements in Human Induced Pluripotent Stem Cells and Somatic Cells. Circ Res 121:1237-1250
Xiang, Yangfei; Tanaka, Yoshiaki; Patterson, Benjamin et al. (2017) Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration. Cell Stem Cell 21:383-398.e7
Zhao, Ming-Tao; Chen, Haodong; Liu, Qing et al. (2017) Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs. Proc Natl Acad Sci U S A 114:E11111-E11120
Hysolli, Eriona; Tanaka, Yoshiaki; Su, Juan et al. (2016) Regulation of the DNA Methylation Landscape in Human Somatic Cell Reprogramming by the miR-29 Family. Stem Cell Reports 7:43-54
Zhang, Xiaoyan; Marjani, Sadie L; Hu, Zhaoyang et al. (2016) Single-Cell Sequencing for Precise Cancer Research: Progress and Prospects. Cancer Res 76:1305-12
Hu, Shijun; Zhao, Ming-Tao; Jahanbani, Fereshteh et al. (2016) Effects of cellular origin on differentiation of human induced pluripotent stem cell-derived endothelial cells. JCI Insight 1:
Liu, Renjing; Kim, Kun-Yong; Jung, Yong-Wook et al. (2016) Dnmt1 regulates the myogenic lineage specification of muscle stem cells. Sci Rep 6:35355
He, Chunjiang; Hu, Hanyang; Wilson, Kitchener D et al. (2016) Systematic Characterization of Long Noncoding RNAs Reveals the Contrasting Coordination of Cis- and Trans-Molecular Regulation in Human Fetal and Adult Hearts. Circ Cardiovasc Genet 9:110-8
Burridge, Paul W; Diecke, Sebastian; Matsa, Elena et al. (2016) Modeling Cardiovascular Diseases with Patient-Specific Human Pluripotent Stem Cell-Derived Cardiomyocytes. Methods Mol Biol 1353:119-30

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