Core Structure The core will be overseen by Dr. Snyder and be managed by an Executive Committee comprised of Drs. Snyder, Wu, Weissman, Wysocka, and Koller. To avoid conflict of interest and to have a broader representation from the rest of the University, we will also have Dr. Irving Weissman (Director, Stanford Stem Cell Institute), Dr. Michael Longaker (co-Director, Stanford Stem Cell Institute), and Dr. Robert Robbins (Director, Stanford Cardiovascular Institute) as external panel members (see support letters). This core will meet biweekly physically (for the Stanford Pis) and by teleconference (for Weissman) and review scientific progress and discuss directions. The Executive Committee will also review pilot project proposals. It is expected that all decisions will be met by consensus, but in the unlikely event that this is not possible, Dr. Snyder is responsible for final decisions. The Executive Committee will also interface with other funded members of the consortium which will allow us to coordinate activities with other groups. If this format is not followed in this initiative, then an external advisory board comprised of prominent members in the iPSC and genomics communities will be formed and meet annually with our group. Scientific coordination will be mediated by Shin Lin, who is experienced with many of the techniques proposed and knows most of the Pis. He will be responsible for the day-to-day management of the entire operation. He will also be heavily engaged in Project 3. Communication between participants will be facilitated by Ms. Christina Pack, who will assist Dr. Snyder and also be responsible for interface with other members of the epigenetic consortium.

Agency
National Institute of Health (NIH)
Type
Research Program Projects (P01)
Project #
5P01GM099130-04
Application #
8730683
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Stanford University
Department
Type
DUNS #
City
Stanford
State
CA
Country
United States
Zip Code
94304
Han, Lin; Zi, Xiaoyuan; Garmire, Lana X et al. (2014) Co-detection and sequencing of genes and transcripts from the same single cells facilitated by a microfluidics platform. Sci Rep 4:6485
Dan, Jiameng; Liu, Yifei; Liu, Na et al. (2014) Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. Dev Cell 29:7-19
Benayoun, Bérénice A; Pollina, Elizabeth A; Ucar, Duygu et al. (2014) H3K4me3 breadth is linked to cell identity and transcriptional consistency. Cell 158:673-88
Tanaka, Yoshiaki; Kim, Kun-Yong; Zhong, Mei et al. (2014) Transcriptional regulation in pluripotent stem cells by methyl CpG-binding protein 2 (MeCP2). Hum Mol Genet 23:1045-55
Guo, Shangqin; Zi, Xiaoyuan; Schulz, Vincent P et al. (2014) Nonstochastic reprogramming from a privileged somatic cell state. Cell 156:649-62
Kim, Kun-Yong; Hysolli, Eriona; Tanaka, Yoshiaki et al. (2014) X Chromosome of female cells shows dynamic changes in status during human somatic cell reprogramming. Stem Cell Reports 2:896-909
Liu, Na; Liu, Lin; Pan, Xinghua (2014) Single-cell analysis of the transcriptome and its application in the characterization of stem cells and early embryos. Cell Mol Life Sci 71:2707-15
Ebert, Antje D; Kodo, Kazuki; Liang, Ping et al. (2014) Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system. Sci Transl Med 6:255ra130
Buecker, Christa; Srinivasan, Rajini; Wu, Zhixiang et al. (2014) Reorganization of enhancer patterns in transition from naive to primed pluripotency. Cell Stem Cell 14:838-53
Sanchez-Freire, Veronica; Lee, Andrew S; Hu, Shijun et al. (2014) Effect of human donor cell source on differentiation and function of cardiac induced pluripotent stem cells. J Am Coll Cardiol 64:436-48

Showing the most recent 10 out of 24 publications