The Administrative Core will support all of the Projects and the Bioinformatics Core of this Program. Kathrin Plath, Program PI, will be the Leader of the Administrative Core, with support from Drs. Smale and Zaret as Co-Investigators. This Core will enable all of the scientific components of the Program to interact by providing the structure and financial support for regular planning, sharing, and evaluation of the research. The Core will be responsible for ensuring that the investigators act as a cohesive and interactive group by providing the planning and leadership required for regular and frequent interactions among the Projects and the Bioinformatics Core. A shared Web site will support the projects with integrated services for optimal quality, efficiency, and data-sharing. In addition, the core will ensure efficient collaborations with the existing stem cell research centers at UCLA and UPenn to provide optimal access to basic resources and infrastructure and leverage existing high-throughput sequencing, microarray, and stem cell resources at the respective institutions. The Core will recruit additional investigators to the study of human cell pluripotency and reprogramming through the distribution of pilot projects. The Administrative Core will also provide centralized grant administration, including coordinating interactions of the investigators. Core usage, reporting to the NIGMS, budget oversight and management, and ensuring compliance with all governing IBC and ESCRO regulations and policies. Program interactions and oversight will be facilitated by a Scientific Advisory Board composed of both internal and external experts in stem cell biology and epigenetics.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
5P01GM099134-03
Application #
8520354
Study Section
Special Emphasis Panel (ZGM1-GDB-8)
Project Start
2013-08-01
Project End
2016-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
3
Fiscal Year
2013
Total Cost
$475,620
Indirect Cost
$95,574
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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Zaret, Kenneth S; Lerner, Jonathan; Iwafuchi-Doi, Makiko (2016) Chromatin Scanning by Dynamic Binding of Pioneer Factors. Mol Cell 62:665-7
Germanguz, I; Listgarten, J; Cinkornpumin, J et al. (2016) Identifying gene expression modules that define human cell fates. Stem Cell Res 16:712-24
Becker, Justin S; Nicetto, Dario; Zaret, Kenneth S (2016) H3K9me3-Dependent Heterochromatin: Barrier to Cell Fate Changes. Trends Genet 32:29-41
White, Andrew; Flores, Aimee; Ong, Jessica et al. (2016) Hmga2 is dispensable for cutaneous squamous cell carcinoma. Exp Dermatol 25:409-12
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Zaret, Kenneth S; Mango, Susan E (2016) Pioneer transcription factors, chromatin dynamics, and cell fate control. Curr Opin Genet Dev 37:76-81
Patel, Sanjeet; Bonora, Giancarlo; Sahakyan, Anna et al. (2016) Human Embryonic Stem Cells Do Not Change Their X Inactivation Status during Differentiation. Cell Rep :
Pastor, William A; Chen, Di; Liu, Wanlu et al. (2016) Naive Human Pluripotent Cells Feature a Methylation Landscape Devoid of Blastocyst or Germline Memory. Cell Stem Cell 18:323-9
Gu, Wen; Gaeta, Xavier; Sahakyan, Anna et al. (2016) Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State. Cell Stem Cell 19:476-490

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