Five senior statistical and quantitative geneticists request Program Project support to enable them to work synergistically on the development and application of statistical methodology for the interpretation of large- scale genomic data and the characterization of the genetic architecture of complex traits. The program will be headed by Bruce Weir, Professor and Chair of Biostatistics at the University of Washington. His project is concerned with developing methodology for characterizing the associations among sets of alleles. Sharon Browning, Research Associate Professor of Biostatistics at the University of Washington, will work on methodology for the analysis of rare variant data. Greg Gibson, Professor of Biology at the Georgia Tech University, proposes an empirical investigation of rare variants with 96 gene expression traits in human peripheral blood from 2,100 individuals from four cohorts. Elizabeth Thompson, Professor of Statistics at the University of Washington, has an overall objective of the development of methods for the enhanced detection and resolution of genes contributing to complex quantitative genetic traits. Her approach will be through using dense SNP marker data for the detection and estimation of segments of gene identity by descent (ibd) shared among sets of individuals. Peter Visscher, Senior Principal Research Fellow at Queensland Institute, will develop and implement better methods to dissect trait variation and predict phenotypes from SNP and sequence data.

Public Health Relevance

This program project grant will support five highly successful statistical and quantitative geneticists to work synergistically on the development and application of statistical methodology for the interpretation of large- scale genomic data and the characterization of the genetic architecture of complex traits. Significance: 2 Investigator(s): 1 Innovation: 2 Approach: 2 Environment: 1

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
1P01GM099568-01
Application #
8214159
Study Section
Special Emphasis Panel (ZRG1-GGG-M (40))
Program Officer
Eckstrand, Irene A
Project Start
2012-06-05
Project End
2017-04-30
Budget Start
2012-06-05
Budget End
2013-04-30
Support Year
1
Fiscal Year
2012
Total Cost
$1,421,545
Indirect Cost
$321,975
Name
University of Washington
Department
Biostatistics & Other Math Sci
Type
Schools of Public Health
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Weir, Bruce S; Goudet, Jérôme (2017) A Unified Characterization of Population Structure and Relatedness. Genetics 206:2085-2103
Brown, Lisa A; Sofer, Tamar; Stilp, Adrienne M et al. (2017) Admixture Mapping Identifies an Amerindian Ancestry Locus Associated with Albuminuria in Hispanics in the United States. J Am Soc Nephrol 28:2211-2220
Chen, Guo-Bo; Lee, Sang Hong; Montgomery, Grant W et al. (2017) Performance of risk prediction for inflammatory bowel disease based on genotyping platform and genomic risk score method. BMC Med Genet 18:94
Pappas, D J; Lizee, A; Paunic, V et al. (2017) Significant variation between SNP-based HLA imputations in diverse populations: the last mile is the hardest. Pharmacogenomics J :
Visscher, Peter M; Wray, Naomi R; Zhang, Qian et al. (2017) 10 Years of GWAS Discovery: Biology, Function, and Translation. Am J Hum Genet 101:5-22
Wang, Bowen; Sverdlov, Serge; Thompson, Elizabeth (2017) Efficient Estimation of Realized Kinship from Single Nucleotide Polymorphism Genotypes. Genetics 205:1063-1078
Marigorta, Urko M; Denson, Lee A; Hyams, Jeffrey S et al. (2017) Transcriptional risk scores link GWAS to eQTLs and predict complications in Crohn's disease. Nat Genet 49:1517-1521
Zeng, Biao; Lloyd-Jones, Luke R; Holloway, Alexander et al. (2017) Constraints on eQTL Fine Mapping in the Presence of Multisite Local Regulation of Gene Expression. G3 (Bethesda) 7:2533-2544
Hodonsky, Chani J; Jain, Deepti; Schick, Ursula M et al. (2017) Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos. PLoS Genet 13:e1006760
Zhan, Xiang; Zhao, Ni; Plantinga, Anna et al. (2017) Powerful Genetic Association Analysis for Common or Rare Variants with High-Dimensional Structured Traits. Genetics 206:1779-1790

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