Five senior statistical and quantitative geneticists request Program Project support to enable them to work synergistically on the development and application of statistical methodology for the interpretation of large- scale genomic data and the characterization of the genetic architecture of complex traits. The program will be headed by Bruce Weir, Professor and Chair of Biostatistics at the University of Washington. His project is concerned with developing methodology for characterizing the associations among sets of alleles. Sharon Browning, Research Associate Professor of Biostatistics at the University of Washington, will work on methodology for the analysis of rare variant data. Greg Gibson, Professor of Biology at the Georgia Tech University, proposes an empirical investigation of rare variants with 96 gene expression traits in human peripheral blood from 2,100 individuals from four cohorts. Elizabeth Thompson, Professor of Statistics at the University of Washington, has an overall objective of the development of methods for the enhanced detection and resolution of genes contributing to complex quantitative genetic traits. Her approach will be through using dense SNP marker data for the detection and estimation of segments of gene identity by descent (ibd) shared among sets of individuals. Peter Visscher, Senior Principal Research Fellow at Queensland Institute, will develop and implement better methods to dissect trait variation and predict phenotypes from SNP and sequence data.

Public Health Relevance

This program project grant will support five highly successful statistical and quantitative geneticists to work synergistically on the development and application of statistical methodology for the interpretation of large- scale genomic data and the characterization of the genetic architecture of complex traits. Significance: 2 Investigator(s): 1 Innovation: 2 Approach: 2 Environment: 1

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
3P01GM099568-02S2
Application #
8796092
Study Section
Special Emphasis Panel (ZRG1-GGG-M (40))
Program Officer
Eckstrand, Irene A
Project Start
2012-06-05
Project End
2017-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
2
Fiscal Year
2014
Total Cost
$51,915
Indirect Cost
$13,625
Name
University of Washington
Department
Biostatistics & Other Math Sci
Type
Schools of Public Health
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Shirasaka, Y; Chaudhry, A S; McDonald, M et al. (2016) Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content. Pharmacogenomics J 16:375-87
Fohner, Alison E; Wang, Zhican; Yracheta, Joseph et al. (2016) Genetics, Diet, and Season Are Associated with Serum 25-Hydroxycholecalciferol Concentration in a Yup'ik Study Population from Southwestern Alaska. J Nutr 146:318-25
Fu, Wenqing; Browning, Sharon R; Browning, Brian L et al. (2016) Robust Inference of Identity by Descent from Exome-Sequencing Data. Am J Hum Genet 99:1106-1116
Chen, Han; Wang, Chaolong; Conomos, Matthew P et al. (2016) Control for Population Structure and Relatedness for Binary Traits in Genetic Association Studies via Logistic Mixed Models. Am J Hum Genet 98:653-66
Browning, Brian L; Browning, Sharon R (2016) Genotype Imputation with Millions of Reference Samples. Am J Hum Genet 98:116-26
Morrison, Jean; Laurie, Cathy C; Marazita, Mary L et al. (2016) Genome-wide association study of dental caries in the Hispanic Communities Health Study/Study of Latinos (HCHS/SOL). Hum Mol Genet 25:807-16
Zheng, Xiuwen; Weir, Bruce S (2016) Eigenanalysis of SNP data with an identity by descent interpretation. Theor Popul Biol 107:65-76
Gratten, Jacob; Visscher, Peter M (2016) Genetic pleiotropy in complex traits and diseases: implications for genomic medicine. Genome Med 8:78
Schick, Ursula M; Jain, Deepti; Hodonsky, Chani J et al. (2016) Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans. Am J Hum Genet 98:229-42
Zhao, Jing; Akinsanmi, Idowu; Arafat, Dalia et al. (2016) A Burden of Rare Variants Associated with Extremes of Gene Expression in Human Peripheral Blood. Am J Hum Genet 98:299-309

Showing the most recent 10 out of 92 publications