Genetic association analysis of rare variants is an area of growing importance in genetics. Rare variants may explain a large portion of the tieritability that has not been explained by common variants, and will lead to new insights into the aetiology of common diseases. Increasing amounts of sequence data are being generated in order to investigate rare variants;however, statistical methods for analysis of these data are in their infancy. We will develop statistical methodology to leverage genome-wide association data for rare variant analysis through imputation, haplotypic testing and selection of samples for sequencing, and we will compare methods for rare variant association analysis. We will also develop statistical methodology to detect population structure and correct for it in association analysis, with a particular focus on rare variant analysis.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
5P01GM099568-03
Application #
8668088
Study Section
Special Emphasis Panel (ZRG1-GGG-M)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
3
Fiscal Year
2014
Total Cost
$226,558
Indirect Cost
$71,794
Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
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