The overall success ofthe POl program "Hormonal Regulation of Ovarian Differentiation" is primarily determined by the commitment and abilities of the participating investigators and by their capacity to effectively interact with each other. But a significant secondary determinant of success is the establishment and maintenance of an efficient and effective administrative structure that allows the POl program investigators to focus on their science and thus maximize their research progress. Providing this support function is the objective ofthe Administrative Core, Core A.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD021921-25
Application #
8519488
Study Section
Special Emphasis Panel (ZHD1-DSR-L)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
25
Fiscal Year
2013
Total Cost
$161,453
Indirect Cost
$85,401
Name
Northwestern University at Chicago
Department
Type
DUNS #
160079455
City
Evanston
State
IL
Country
United States
Zip Code
60201
Que, Emily L; Bleher, Reiner; Duncan, Francesca E et al. (2015) Quantitative mapping of zinc fluxes in the mammalian egg reveals the origin of fertilization-induced zinc sparks. Nat Chem 7:130-9
Kong, Betty Y; Duncan, Francesca E; Que, Emily L et al. (2015) The inorganic anatomy of the mammalian preimplantation embryo and the requirement of zinc during the first mitotic divisions. Dev Dyn 244:935-47
Kim, So-Youn; Ebbert, Katherine; Cordeiro, Marilia H et al. (2015) Cell autonomous phosphoinositide 3-kinase activation in oocytes disrupts normal ovarian function through promoting survival and overgrowth of ovarian follicles. Endocrinology 156:1464-76
Cordeiro, Marília H; Kim, So-Youn; Ebbert, Katherine et al. (2015) Geography of follicle formation in the embryonic mouse ovary impacts activation pattern during the first wave of folliculogenesis. Biol Reprod 93:88
Xiao, Shuo; Duncan, Francesca E; Bai, Lu et al. (2015) Size-specific follicle selection improves mouse oocyte reproductive outcomes. Reproduction 150:183-92
Xiao, Shuo; Zhang, Jiyang; Romero, Megan M et al. (2015) In vitro follicle growth supports human oocyte meiotic maturation. Sci Rep 5:17323
Vanorny, Dallas A; Prasasya, Rexxi D; Chalpe, Abha J et al. (2014) Notch signaling regulates ovarian follicle formation and coordinates follicular growth. Mol Endocrinol 28:499-511
Kong, B Y; Duncan, F E; Que, E L et al. (2014) Maternally-derived zinc transporters ZIP6 and ZIP10 drive the mammalian oocyte-to-egg transition. Mol Hum Reprod 20:1077-89
Hong, Young Pyo; Gleber, Sophie-Charlotte; O'Halloran, Thomas V et al. (2014) Alignment of low-dose X-ray fluorescence tomographyýýimages using differential phase contrast. J Synchrotron Radiat 21:229-34
Makanji, Yogeshwar; Zhu, Jie; Mishra, Rama et al. (2014) Inhibin at 90: from discovery to clinical application, a historical review. Endocr Rev 35:747-94

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