The Microimaqinq Core provides training and maintains the many compound and stereo microscopes required for the proposed projects. The Microimaging Core also provides several confocal microscopes, a spinning disk microscope, a custom built two-photon laser scanning microscope and a one-of-a-kind, custom light-sheet microscope for use of the Program.

Public Health Relevance

The aims of this Program Project Grant are to understand the developmental basis of phenotypic variation in three human diseases, Fraser syndrome. Usher syndrome and Hirschsprung disease. The four Core Units ~ Administration, Microimaging, Technical Support and Zebrafish Facility ~ provide the administrative and technical support required to accomplish the Aims of the Component Projects within this Program Project Grant.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Program Projects (P01)
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Special Emphasis Panel (ZHD1-DSR-Y)
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University of Oregon
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Blanco-Sánchez, Bernardo; Clément, Aurélie; Fierro Jr, Javier et al. (2014) Complexes of Usher proteins preassemble at the endoplasmic reticulum and are required for trafficking and ER homeostasis. Dis Model Mech 7:547-59
McMenamin, Sarah K; Bain, Emily J; McCann, Anna E et al. (2014) Thyroid hormone-dependent adult pigment cell lineage and pattern in zebrafish. Science 345:1358-61
Santos, M Emília; Braasch, Ingo; Boileau, Nicolas et al. (2014) The evolution of cichlid fish egg-spots is linked with a cis-regulatory change. Nat Commun 5:5149
Beahm, Brendan J; Dehnert, Karen W; Derr, Nicolas L et al. (2014) A visualizable chain-terminating inhibitor of glycosaminoglycan biosynthesis in developing zebrafish. Angew Chem Int Ed Engl 53:3347-52
DeLaurier, April; Huycke, Tyler R; Nichols, James T et al. (2014) Role of mef2ca in developmental buffering of the zebrafish larval hyoid dermal skeleton. Dev Biol 385:189-99
Kimmel, Charles B (2014) Skull developmental modularity: a view from a single bone - or two. J Appl Ichthyol 30:600-607
Beck, Bodo B; Phillips, Jennifer B; Bartram, Malte P et al. (2014) Mutation of POC1B in a severe syndromic retinal ciliopathy. Hum Mutat 35:1153-62
Sheehan-Rooney, Kelly; Swartz, Mary E; Zhao, Feng et al. (2013) Ahsa1 and Hsp90 activity confers more severe craniofacial phenotypes in a zebrafish model of hypoparathyroidism, sensorineural deafness and renal dysplasia (HDR). Dis Model Mech 6:1285-91
Paquette, Colleen E; Kent, Michael L; Buchner, Cari et al. (2013) A retrospective study of the prevalence and classification of intestinal neoplasia in zebrafish (Danio rerio). Zebrafish 10:228-36
Rodriguez-Mari, Adriana; Canestro, Cristian; BreMiller, Ruth A et al. (2013) Retinoic acid metabolic genes, meiosis, and gonadal sex differentiation in zebrafish. PLoS One 8:e73951

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