The Microimaqinq Core provides training and maintains the many compound and stereo microscopes required for the proposed projects. The Microimaging Core also provides several confocal microscopes, a spinning disk microscope, a custom built two-photon laser scanning microscope and a one-of-a-kind, custom light-sheet microscope for use of the Program.
The aims of this Program Project Grant are to understand the developmental basis of phenotypic variation in three human diseases, Fraser syndrome. Usher syndrome and Hirschsprung disease. The four Core Units ~ Administration, Microimaging, Technical Support and Zebrafish Facility ~ provide the administrative and technical support required to accomplish the Aims of the Component Projects within this Program Project Grant.
|Parthasarathy, Raghuveer (2017) Monitoring microbial communities using light sheet fluorescence microscopy. Curr Opin Microbiol 43:31-37|
|Sullivan, Con; Lage, Christopher R; Yoder, Jeffrey A et al. (2017) Evolutionary divergence of the vertebrate TNFAIP8 gene family: Applying the spotted gar orthology bridge to understand ohnolog loss in teleosts. PLoS One 12:e0179517|
|Melancon, E; Gomez De La Torre Canny, S; Sichel, S et al. (2017) Best practices for germ-free derivation and gnotobiotic zebrafish husbandry. Methods Cell Biol 138:61-100|
|Kroeger Jr, Paul T; Drummond, Bridgette E; Miceli, Rachel et al. (2017) The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development. Dev Biol 428:148-163|
|Yan, Yi-Lin; Desvignes, Thomas; Bremiller, Ruth et al. (2017) Gonadal soma controls ovarian follicle proliferation through Gsdf in zebrafish. Dev Dyn 246:925-945|
|Taormina, Michael J; Hay, Edouard A; Parthasarathy, Raghuveer (2017) Passive and Active Microrheology of the Intestinal Fluid of the Larval Zebrafish. Biophys J 113:957-965|
|Wangler, Michael F; Yamamoto, Shinya; Chao, Hsiao-Tuan et al. (2017) Model Organisms Facilitate Rare Disease Diagnosis and Therapeutic Research. Genetics 207:9-27|
|Rolig, Annah S; Mittge, Erika K; Ganz, Julia et al. (2017) The enteric nervous system promotes intestinal health by constraining microbiota composition. PLoS Biol 15:e2000689|
|Blanco-Sánchez, B; Clément, A; Phillips, J B et al. (2017) Zebrafish models of human eye and inner ear diseases. Methods Cell Biol 138:415-467|
|Postlethwait, John H; Yan, Yi-Lin; Desvignes, Thomas et al. (2016) Embryogenesis and early skeletogenesis in the antarctic bullhead notothen, Notothenia coriiceps. Dev Dyn 245:1066-1080|
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