Abstract

The COREs will provide scientific support and statistical services exclusively for members of this program project. Dr. Stuart A. Lipton is responsible for overall scientific and administrative aspects of the CORE and will oversee budget, progress, and financial reports and ensure the scientific merit of the work performed under the program project grant. The scientific aspects of the CORE will be also overseen on a dayto- day basis by Dr. Dongxian Zhang. The CORE is divided into an Administrative/Statistical CORE (see B, below) and a Neuroscience Research CORE Facilities for Tissue Culture and for NMDAR Crystallography/Modeling (see C, below). In the Administrative/Statistical CORE, service is provided to all three projects for expertise of a trained statistician (5% time), who serves the needs of the projects as they design the specifics of their experiments and analyze their data. In the Neuroscience Research CORE, service is provided to all three projects for the following: (1) technical assistance in preparation of cells for tissue culture, and/or for (2) analysis of the effects of NMDAR antagonists in protecting the brain from hypoxic-ischemic insults. All projects will share in the services of this Neuroscience CORE

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
3P01HD029587-16S2
Application #
8231888
Study Section
Pediatrics Subcommittee (CHHD)
Project Start
2009-09-01
Project End
2011-11-30
Budget Start
2009-09-01
Budget End
2011-11-30
Support Year
16
Fiscal Year
2011
Total Cost
$83,368
Indirect Cost

  Institution

Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
020520466
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Mann, Aman P; Scodeller, Pablo; Hussain, Sazid et al. (2018) Publisher Correction: Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer's disease. Nat Commun 9:1070
Nagar, Saumya; Noveral, Sarah M; Trudler, Dorit et al. (2017) MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress. Proc Natl Acad Sci U S A 114:E4048-E4056
Mann, Aman P; Scodeller, Pablo; Hussain, Sazid et al. (2017) Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer's disease. Nat Commun 8:1403
Tu, Shichun; Akhtar, Mohd Waseem; Escorihuela, Rosa Maria et al. (2017) NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism. Nat Commun 8:1488
Satoh, Takumi; Lipton, Stuart (2017) Recent advances in understanding NRF2 as a druggable target: development of pro-electrophilic and non-covalent NRF2 activators to overcome systemic side effects of electrophilic drugs like dimethyl fumarate. F1000Res 6:2138
Nakamura, Tomohiro; Lipton, Stuart A (2017) 'SNO'-Storms Compromise Protein Activity and Mitochondrial Metabolism in Neurodegenerative Disorders. Trends Endocrinol Metab 28:879-892
Chen, Shanyan; Cui, Jiankun; Jiang, Tao et al. (2017) Gelatinase activity imaged by activatable cell-penetrating peptides in cell-based and in vivo models of stroke. J Cereb Blood Flow Metab 37:188-200
Nagar, Saumya; Trudler, Dorit; McKercher, Scott R et al. (2017) Molecular Pathway to Protection From Age-Dependent Photoreceptor Degeneration in Mef2 Deficiency. Invest Ophthalmol Vis Sci 58:3741-3749
Akhtar, Mohd Waseem; Sanz-Blasco, Sara; Dolatabadi, Nima et al. (2016) Elevated glucose and oligomeric ?-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation. Nat Commun 7:10242
Sanz-Blasco, Sara; Piña-Crespo, Juan C; Zhang, Xiaofei et al. (2016) Levetiracetam inhibits oligomeric A?-induced glutamate release from human astrocytes. Neuroreport 27:705-9

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