PROJECT SUMIVIARY (See instructions): The Administrative and Statistical Core (CORE A) is overseen by the PI, Dr. Lipton. This Core organizes and handles supply ordering, equipment maintenance, budgets, preparation of grant reports and manuscripts, scheduling of weekly Program Meetings, scheduling relevant seminars, and other administrative duties of the Program Project. Since ordering is centralized for all members of the Program Project, an economies of scale will be achieved by insuring that duplicate orders do not occur between the various projects and cores, and also that the various projects and cores can share similar orders. Additionally by ordering in bulk for the entire Program Project, discounts can often be obtained. The Statistical Services ofthe Core will be provided by Professor lan Abramson, a Ph.D. statistician who is expert in this area and housed in the nearby Department of Mathematics at UC San Diego, where the P.I., Dr. Lipton, also has a co-appointment. The statistical component of the Core will provide statistical assistance with experimental design, data evaluation, and manuscript preparation. Statistial services are extremely important to several aspects of the planned experiments analyzing the effectiveness of NMDA receptor antagonists and related molecules in ameliorating cognitve dysfunction in animal models (and eventually humans) with Down syndrome (DS). Power analyses performed by the Statistician are useful in planning how many animals will be required for a given experiment in order to have adequate probability of detection of an expected difference. Project I will use the Statistician to analyze data for significance. Projects II and III will use Power Analyses to plan experiments in terms of how many animals need to be tested in each paradigm. All three projects will order supplies by the Administrative Core and use the secretarial/managerial sen/ices provided.
The Administrative/Statistical Core will provide support services to this Program Grant to allow the projects to pursue model systems in which we can study the influence of NMDA receptors and related molecules in protecting nerve cells from damage in Down syndrome (DS). The Core serves the S projects in this Program Project that have a unified goal to find new treatments for cognitive deficits in DS.
|Okamoto, Shu-ichi; Lipton, Stuart A (2015) S-Nitrosylation in neurogenesis and neuronal development. Biochim Biophys Acta 1850:1588-93|
|Zhu, Saiyong; Ambasudhan, Rajesh; Sun, Woong et al. (2014) Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells. Cell Res 24:126-9|
|Jeon, Gye Sun; Nakamura, Tomohiro; Lee, Jeong-Seon et al. (2014) Potential effect of S-nitrosylated protein disulfide isomerase on mutant SOD1 aggregation and neuronal cell death in amyotrophic lateral sclerosis. Mol Neurobiol 49:796-807|
|Chan, Shing Fai; Sances, Sam; Brill, Laurence M et al. (2014) ATM-dependent phosphorylation of MEF2D promotes neuronal survival after DNA damage. J Neurosci 34:4640-53|
|Choi, Min Sik; Nakamura, Tomohiro; Cho, Seung-Je et al. (2014) Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models. J Neurosci 34:15123-31|
|Okamoto, Shu-Ichi; Nakamura, Tomohiro; Cieplak, Piotr et al. (2014) S-nitrosylation-mediated redox transcriptional switch modulates neurogenesis and neuronal cell death. Cell Rep 8:217-28|
|Molokanova, Elena; Akhtar, Mohd Waseem; Sanz-Blasco, Sara et al. (2014) Differential effects of synaptic and extrasynaptic NMDA receptors on A?-induced nitric oxide production in cerebrocortical neurons. J Neurosci 34:5023-8|
|Marco, Sonia; Giralt, Albert; Petrovic, Milos M et al. (2013) Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models. Nat Med 19:1030-8|
|Sunico, Carmen R; Nakamura, Tomohiro; Rockenstein, Edward et al. (2013) S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease. Mol Neurodegener 8:29|
|Talantova, Maria; Sanz-Blasco, Sara; Zhang, Xiaofei et al. (2013) A? induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. Proc Natl Acad Sci U S A 110:E2518-27|
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